Summary
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1.
The adrenergic receptors in the systemic vasculature of the rainbow trout have been pharmacologically characterized using an isolated trunk preparation perfused at constant flow.
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2.
The dominant α-constrictory receptors in the trunk are similar to those of mammals in their adrenaline/noradrenaline potency ratio (3.2/1.0), and in the natures of their blockade by phenoxybenzamine and yohimbine. However they are more selective than mammalian α-receptors, responding directly to only adrenaline and noradrenaline, and not to phenylephrine, methoxamine, dopamine, or isoprenaline.
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3.
Tyramine and dopamine cause weak α-adrenergic constriction, apparently indirectly through the release of catecholamine stores.
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4.
The α-adrenergic response is susceptible to inhibition by competitive β-blocking agents, but this effect is due to non-competitive antagonism with a point of action beyond the adrenergic receptor.
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5.
β-dilatory receptors of the β2, as in the homologous systemic vasculature of mammals, also apparently occur, but their dilatory actions cn only be demonstrated against a background of α-adrenergic vasoconstriction.
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6.
The racemate d,l-isoprenaline is a more potent vasodilator than the pure isomer l-isoprenaline during α-adrenergic tone because of the competitive α-blocking activity of the d-isomer.
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Abbreviations
- R s :
-
systemic vascular resistance
- AD:
-
adrenaline
- NAD:
-
noradrenaline
- ISO:
-
isoprenaline
- PHE:
-
phenylephrine
References
Ahlquist, R.P.: A study of the adrenotropic receptors. Amer. J. Physiol.153, 586–600 (1948)
Ariens, E.J.: Molecular pharmacology. New York: Academic Press 1964
Arnold, A.: Differentiation of receptors activated by catecholamines. III. Farmaco27, 79–100 (1972)
Belaud, A., Peyraud-Waitzenegger, M., Peyraud, C.: Etude comparée des réactions vasomotrices des branchies perfusées de deux Téléostéens: la Carpe et le Congre. C.R. Soc. Biol. (Paris)165, 1114–1118 (1971)
Bergman, H.L., Olson, K.R., Fromm, P.O.: The effects of vasoactive agents on the functional surface area of isolated perfused gills of the rainbow trout. J. comp. Physiol.94, 267–286 (1974)
Boyd, H., Burnstock, G., Campbell, G., Jowett, A., O'Shea, J.A., Wood, M.: An investigation of the use of adrenergic blocking agents as physiological tools. Aust. J. Sci.25, 107 (1962)
Burnstock, G., Kirby, S.: Absence of inhibitory effects of catecholamines on lower vertebrate arterial strip preparations. J. Pharm. Pharmac.20, 404–406 (1968)
Chan, D.K.O.: Hormonal and haemodynamic factors in the control of water and electrolyte fluxes in the European eelAnguilla anguilla. Ph.D. thesis, University of Sheffield, Department of Zoology (1967)
Duncan, D.B.: Multiple range and multiple F tests. Biometrics11, 1–42 (1955)
Furchgott, R.F.: The pharmacological differentiation of adrenergic receptors. Ann. N.Y. Acad. Sci.139, 553–570 (1967)
Furchgott, R.F.: Pharmacological characteristics of adrenergic receptors. Fed. Proc.29, 1352–1361 (1970)
Furchgott, R.F., Bhadrakom, S.: Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite, and other drugs. J. Pharmacol. exp. Ther.108, 129–143 (1953)
Goldberg, L.I.: Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol. Rev.24, 1–29 (1972)
Helgason, A., Nilsson, S.: Drug effects on pre- and post-branchial blood pressure and heart rate in a free-swimming marine teleost,Gadus morhua. Acta physiol. scand.88, 533–540 (1973)
Holmgren, S., Nilsson, S.: Drug effects on isolated artery strips from two teleosts,Gadus morhua andSalmo gairdneri. Acta physiol. scand.90, 431–437 (1974)
Innes, I.R., Nickerson, M.: Drugs acting on postganglionic adrenergic nerve endings and structures innervated by them (sympathomimetic drugs). In: The pharmacological basis of therapeutics, 4th ed. (L.S. Goodman, A. Gilman, eds.). London: MacMillan 1970
Jenkinson, D.H.: Classification and properties of peripheral adrenergic receptors. Brit. med. Bull.29, 142–147 (1973)
Johansen, K., Reite, O.B.: Influence of acetylcholine and biogenic amines on branchial, pulmonary, and systemic vascular resistance in the African lungfish,Protopterus aethiopicus. Acta physiol. scand.74, 465–471 (1968)
Kirby, S., Burnstock, G.: Comparative pharmacological studies of isolated spiral strips of large arteries from lower vertebrates. Comp. Biochem. Physiol.28, 307–319 (1969)
Kohli, J.D., Ling, G.M.: α-adrenergic blocking action of propranolol. J. Pharm. Pharmac.19, 629–631 (1967)
Kramer, C.Y.: Extension of multiple range tests to group means with unequal numbers of replications. Biometrics12, 307–310 (1956)
Moran, N.C.: The development of beta-adrenergic blocking drugs: a retrospective and prospective evaluation. Ann. N.Y. Acad. Sci.139, 649–660 (1967)
Nickerson, M.: Drugs inhibiting adrenergic nerves and structures innervated by them. In: The pharmacological basis of therapeutics, 4th ed. (L.S. Goodman, A. Gilman, eds.). London: MacMillan 1970
Nilsson, S.: Autonomic vasomotor innervation in the gas gland of the swim bladder of a teleost (Gadus morhua). Comp. gen. Pharmac.3, 371–375 (1972)
Opdyke, D.F., McGreehan, J.R., Messing, S., Opdyke, N.E.: Cardiovascular responses to spinal cord stimulation and autonomically active drugs inSqualus acanthias. Comp. Biochem. Physiol.42A, 611–620 (1972)
Peiper, U., Griebel, L., Wende, W.: Different mechanisms of activating the vascular smooth muscle by noradrenaline or potassium depolarization. In: Vascular smooth muscle (E. Betz, ed.). Berlin-Heidelberg-New York: Springer 1972
Randall, D.J., Stevens, E.D.: The role of adrenergic receptors in cardiovascular changes associated with exercise in salmon. Comp. Biochem. Physiol.21, 415–424 (1967)
Rankin, J.C., Maetz, J.: A perfused teleostean gill preparation: vascular actions of neurohypophysial hormones and catecholamines. J. Endocr.51, 621–635 (1971)
Reite, O.B.: The evolution of vascular smooth muscle responses to histamine and 5-hydroxytryptamine. I. Occurrence of stimulatory actions in fish. Acta physiol. scand.75, 221–239 (1969)
Schwartz, S.L., Borzelleca, J.F.: Adrenergic blood pressure responses in the shark. Science163, 395–397 (1969)
Sheys, E.M., Green, R.S.: A quantitative study of alpha adrenergic receptors in the spleen and aorta of the rabbit. J. Pharmacol. exp. Ther.180, 317–325 (1972)
Stevens, E.D., Bennion, G.R., Randall, D.J., Shelton, G.: Factors affecting arterial pressures and blood flow from the heart in intact, unrestrained lingcod,Ophiodon elongatus. Comp. Biochem. Physiol.43A, 681–695 (1972)
Stray-Pedersen, S.: Vascular responses induced by drugs and by vagal stimulation in the swimbladder of the eel,Anguilla vulgaris. Comp. gen. Pharmac.1, 358–364 (1970)
Trendelenburg, U.: Supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol. Rev.15, 225–276 (1963)
Wolf, K.: Physiological salines for freshwater teleosts. Progr. Fish. Cult.25, 135–140 (1963)
Wood, C.M.: A critical examination of the physical and adrenergic factors affecting blood flow through the gills of the rainbow trout. J. exp. Biol.60, 241–265 (1974a)
Wood, C.M.: Mayer waves in the circulation of a teleost fish. J. exp. Zool.189, 267–274 (1974b)
Wood, C.M.: A pharmacological analysis of the adrenergic and cholinergic mechanisms regulating branchial vascular resistance in the rainbow trout (Salmo gairdneri). Canad. J. Zool.53, 1569–1577 (1975)
Wood, C.M., Shelton, G.: Physical and adrenergic factors affecting systemic vascular resistance in the rainbow trout: a comparison with branchial vascular resistance. J. exp. Biol.63, 505–523 (1975)
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Wood, C.M. Pharmacological properties of the adrenergic receptors regulating systemic vascular resistance in the rainbow trout. J Comp Physiol B 107, 211–228 (1976). https://doi.org/10.1007/BF00691227
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DOI: https://doi.org/10.1007/BF00691227