Summary
Blood vessels with amyloid angiopathy and senile plaques in the cortices of the brains with Alzheimer's disease and senile dementia were observed by means of a scanning electron microscope.
The results obtained were as follows: The blood vessels with amyloid angiopathy were surrounded by solid substances. The senile plaques consisted of rough solid substances, contained degenerated cell processes, and almost all plaques existed around the degenerated capillaries with amyloid angiopathy.
From the above described findings, we suggest that the senile plaque has an extremely close relationship to the capillary which had undergone amyloid angiopathy.
References
Evan, A. P., Dail, W. G., Dammrose, D., Palmer, C.: Scanning electron microscopy of cell surfaces following removal of extracellular material. Anat. Rec.185, 433–445 (1976)
Miyakawa, T., Sumiyoshi, S., Murayama, E., Deshimaru, M.: Ultrastructure of capillary plaque-like degeneration in senile dementia. Acta Neuropathol. (Berl.)29, 229–236 (1974)
Takahashi, M.: Pathological study on amyloidosis—Scanning electron microscopic observation. Acta Pathol. Jpn.27, 809–822 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Miyakawa, T., Uehara, Y. Observations of amyloid angiopathy and senile plaques by the scanning electron microscope. Acta Neuropathol 48, 153–156 (1979). https://doi.org/10.1007/BF00691158
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00691158