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Hemosiderin deposition in muscle

Report of three cases

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Summary

This report presents the morphological character of iron deposits in muscle biopsies of three patients who have been suffering from secondary hemochromatosis.

The granules observed by light microscopy and located either in the cytoplasm of macrophages or inside muscle fibres are illustrated in electron micrographs. In this study, Thiery's technic, which is a specific and very sensitive reaction, has been very useful to confirm by electron microscopy that these granules contain iron. Such a study in muscle appears to be unique.

In our experience, accumulation of hemosiderin pigment in muscle does not seem to be specific of any disease, but suggests that a hepatic biopsy must be done.

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References

  • Buja, L. M., Roberts, W. C.: Iron in the heart. Etiology and clinical significance. Amer. J. Med.51, 209–221 (1971)

    Google Scholar 

  • Crosby, W. H.: Normal serum ferritin in precirrhotic hemochromatosis. New Engl. J. of Med.296, 1116 (1977)

    Google Scholar 

  • Griggs, R. C., Markebery, W. R., Bauman, A. N., Callemare, M. L.: Perivascular hemosiderin deposition in muscle in Waldenström's macroglobulinemia. J. Neurol. Sci.25, 153–163 (1975)

    Google Scholar 

  • Mac Donald, R. A.: Haemochromatosis and hemosiderosis. Springfield, Ill.: Thomas 1964

    Google Scholar 

  • Nicolas, G., Bouhour, J. B., Delajartre, A., Godin, J. F., Horeau, J.: Myocardiopathie secondaire à l'hémochromatose idiopathique. Quatre observations anatomo-cliniques avec étude du myocarde en microscopie électronique. Arch. Mal. Coeur11, 1533–1556 (1971)

    Google Scholar 

  • Richter, G. W., Bessis, M. C.: Commentary on hemosiderin. Blood25, 370–374 (1965)

    Google Scholar 

  • Sheldon, J. H.: Haemochromatosis. London: Oxford University Press 1935

    Google Scholar 

  • Thiery, J. P.: Etude des réactions cytochimiques du fer au microscope électronique. J. Microscopie1, 127–136 (1962)

    Google Scholar 

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Authors and Affiliations

  1. Departments of Neurology and Pathology, Hôpital Universitaire Dupuytren, F-87000, Limoges, France

    J. M. Vallat, R. Loubet, M. J. Leboutet & A. Loubet

Authors
  1. J. M. Vallat
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  2. R. Loubet
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  3. M. J. Leboutet
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  4. A. Loubet
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Vallat, J.M., Loubet, R., Leboutet, M.J. et al. Hemosiderin deposition in muscle. Acta Neuropathol 42, 153–156 (1978). https://doi.org/10.1007/BF00690984

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  • DOI: https://doi.org/10.1007/BF00690984

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