Summary
The haemodynamic effects of adenosine on gills of the trout (Salmo gairdneri) were studied with in vitro and in vivo preparations.
On the isolated head preparation, adenosine induced a decrease of the ventral aortic inflow and of the dorsal aortic outflow. Simultaneously the venous outflow increased. These effects were antagonized by theophylline. Adenosine induced a vasoconstriction in gill arches without filaments perfused by the afferent or the efferent branchial arteries. The efferent vessels were more sensitive to adenosine than afferent vessels. The whole systemic circulation of the isolated trunk did not show any response to adenosine. When adenosine was infused into the ventral aorta of living trout, the gill resistance to blood flow was greatly increased.
These results suggest that adenosine is able to control the arterious and venous blood pathways in the trout gills by modulating their vascular resistance.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bergman, H.L., Olson, K.R., Fromm, P.O.: The effects of vasoactive agents on the functional surface area of isolated-perfused gills of Rainbow trout. J. Comp. Physiol.94, 267–286 (1974)
Berne, R.M.: Regulation of coronary blood flow. Physiol. Rev.44, 1–29 (1964)
Burnstock, G.: Comparative studies of purinergic nerves. J. Exp. Zool.194, 103–134 (1975)
Burton, A.C.: Physiology and biophysics of the circulation (2nd ed.), pp. 87–88. Chicago, Illinois: Year Book 1972
Cameron, J.N., Davis, J.C.: Gas exchange in Rainbow trout (Salmo gairdneri) with varying blood oxygen capacity. J. Fish. Res. Bd. Can.27, 1069–1085 (1970)
Colin, D., Leray, C.: Réponses hémodynamiques de la branchie á l'adénosine chez la Truite (Salmo gairdneri). Etude sur tète isolee perfusée. C.r. hebd. Séanc. Acad. Sci. Paris284D, 1191–1194 (1977)
Dunel, S., Laurent, P.: Le systéme vasculaire branchial des Téléosteens: premiéres données sur son innervation. J. Physiol. (Paris)73, 4A (1977)
Farmer, J.B., Farrar, D.G.: Pharmacological studies with adenine, adenosine and some phosphorylated derivatives on guinea-pig tracheal muscle. J. Pharm. Pharmacol.28, 748–752 (1976)
Gannon, B.J.: Comparative and developmental studies of autonomic nerves in visceral and cardiovascular systems. Ph. D. Thesis, Melbourne (1972)
Girard, J.P.: Salt excretion by the perfused head of trout adapted to sea water and its inhibition by adrenaline. J. Comp. Physiol.111, 77–91 (1976)
Girard, J.P., Payan, P.: Effect of epinephrine on vascular space of gills and head of Rainbow trout. Am. J. Physiol.230, 1555–1560 (1976)
Haywood, G.P., Isaia, J., Maetz, J.: Epinephrine effects on branchial water and urea flux in rainbow trout. Am. J. Physiol.232, R110-R115 (1977)
Itazawa, Y.: Cardiac output of fish. Bull. Japan Soc. Sci. Fish.36, 926–931 (1970)
Keys, A., Bateman, J.B.: Branchial responses to adrenaline and pitressin in the eel. Biol. Bull. (Woods Hole).63, 327–336 (1932)
Laurent, P., Dunel, S.: Functional organization of the teleost gill. I. Blood pathways. Acta Zool.57, 189–209 (1976)
Leray, C., Raffin, J.P., Winninger, C.: Aspects of purine metabolism in the gill epithelium of Rainbow trout,Salmo gairdneri, R. Comp. Biochem. Physiol.62, 31–40 (1978)
Mackenzie, S.G., Frew, R., Bär, H.-P.: Characteristics of the relaxant response of adenosine and its analogs in intestinal smooth muscle. Eur. J. Pharmacol.41, 183–192 (1977)
Morgan, M., Tovell, P.W.A.: The structure of the gill of the trout,Salmo gairdneri (Richardson). Z. Zellforsch.142, 147–162 (1973)
Olsson, R.A., Davis, C.J., Khouri, E.M., Patterson, R.E.: Evidence for an adenosine receptor on the surface of dog coronary myocytes. Circ. Res.39, 93–98 (1976)
Payan, P., Girard, J.P.: Adrenergic receptors regulating patterns of blood flow through the gills of trout. Am. J. Physiol.232, H18-H23 (1977)
Payan, P., Matty, A.J.: The characteristics of ammonia excretion by a perfused isolated head of trout (Salmo gairdneri): Effect of temperature of CO2-free Ringer. J. Comp. Physiol.96, 167–184 (1975)
Randall, D.J., Smith, L.S., Brett, J.R.: Dorsal aortic blood pressures recorded from the Rainbow trout (Salmo gairdneri). Can. J. Zool.43, 863–872 (1965)
Rankin, J.C., Maetz, J.: A perfused teleostean gill preparation: vascular actions of neurohypophysial hormones and catecholamines. J. Endocr.51, 621–635 (1971)
Richards, B.D., Fromm, P.O.: Patterns of blood flow through filaments and lamellae of isolated-perfused Rainbow trout (Salmo gairdneri) gills. Comp. Biochem. Physiol.29, 1063–1070 (1969)
Schrader, J., Nees, S., Gerlach, E.: Evidence for a cell surface adenosine receptor on coronary myocytes and atrial muscle cells. Pflügers Arch.369, 251–257 (1977)
Smith, D.G.: Sites of cholinergic vasoconstriction in trout gills. Am. J. Physiol.233, R222-R229 (1977)
Stevens, E.D., Randall, D.J.: Changes in blood pressure, heart rate and breathing rate during moderate swimming activity in Rainbow trout. J. Exp. Biol.46, 307–315 (1967)
Tagawa, H., Vander, A.J.: Effects of adenosine compounds on renal function and renin secretion in dogs. Circ. Res.26, 327–338 (1970)
Vogel, W., Vogel, V., Pfautsch, M.: Arterio-venous anastomoses in Rainbow trout gill filaments. Cell Tiss. Res.167, 373–385 (1976)
Wood, C.M.: A critical examination of the physical and adrenergic factors affecting blood flow through the gills of the Rainbow trout. J. Exp. Biol.60, 241–265 (1974)
Wood, C.M.: A pharmacological analysis of the adrenergic and cholinergic mechanisms regulating branchial vascular resistance in the Rainbow trout (Salmo gairdneri). Can. J. Zool.53, 1569–1577 (1975)
Wood, C.M.: Pharmacological properties of the adrenergic receptors regulating systemic vascular resistance in the Rainbow trout. J. Comp. Physiol.107, 211–228 (1976)
Wood, C.M.: Cholinergic mechanisms and the response to ATP in the systemic vasculature of the Rainbow trout. J. Comp. Physiol.122, 325–345 (1977)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Colin, D.A., Kirsch, R. & Leray, C. Haemodynamic effects of adenosine on gills of the trout (Salmo gairdneri). J Comp Physiol B 130, 325–330 (1979). https://doi.org/10.1007/BF00689850
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00689850