Summary
The rate of oxygen consumption (\(\dot V_{O_2 }\)) by skeletal muscle was investigated in isolated perfused hindlimbs of laboratory rats and lemmings (Lemmus). In both species,\(\dot V_{O_2 }\) increased in proportion to blood flow rate, even at flow rates 4–5 times above resting level. The slope of the line relating\(\dot V_{O_2 }\) to skeletal muscle blood flow was significantly greater in the lemming than in the rat. This may be related to the inverse relationship between body weight and metabolic rate. These data support the hypothesis that in small animals a dependent relationship exists between blood flow and skeletal muscle\(\dot V_{O_2 }\).
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Grubb, B., Folk, G.E. Skeletal muscle\(\dot V_{O_2 }\) in rat and lemming: Effect of blood flow rate. J Comp Physiol B 128, 185–188 (1978). https://doi.org/10.1007/BF00689483
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DOI: https://doi.org/10.1007/BF00689483