Skip to main content
SpringerLink
Log in

Cerebral angioendotheliomatosis in a dog

  • Original Works
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

A 6-year-old dog which presented with weakness of the hind limbs progressed to a cerebral disorder with altered sensorium. The cerebrospinal fluid (CSF) protein was elevated, but no cells were found. Autopsy revealed severe hemorrhages in the basal nuclei and diencephalon. Histology of the lesions showed many meningeal and parenchymal blood vessels filled with neoplastic mononuclear cells. Electron microscopy of the tumor cells demonstrated ribosomes, granular endoplasmic reticulum, mitochondria, and a few lysosomes. Immunocytochemical procedures to demonstrate Factor VIII-related antigen were negative. this appears to be the first recorded case of cerebral angioendotheliomatosis in domestic animals and closely resembles the syndrome in man.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ansell J, Bhawan J, Cohen S, Sullivan J, Sherman D (1982) Histiocytic lymphoma and malignant angioendotheliomatosis. Cancer 50:1506–1512

    Google Scholar 

  • Beal MF, Fisher CM (1982) Neoplastic angioendotheliosis. J Neurol Sci 53:359–375

    Google Scholar 

  • Ojeda VJ (1983) Neoplastic angioendotheliosis of the spinal cord. Acta Neuropathol (Berl) 62:164–166

    Google Scholar 

  • Petito CK, Gottlieb GJ, Doherty JH, Petito FA (1978) Neoplastic angioendotheliomatosis: Ultrastructural study and review of the literature. Ann Neurol 3:393–399

    Google Scholar 

  • Pfleger L, Tappeiner J (1959) Zur Kenntnis der systemisierten Endotheliomatose der cutanen Blutgefäße (Reticuloendotheliose?). Hautarzt 10:359–363

    Google Scholar 

  • Sladden RA (1964) Neoplasia of aortic intima. J Clin Pathol 17:602–607

    Google Scholar 

  • Sternberger LA (1979) Immunocytochemistry, 2nd edn. Wiley, New York, pp 104–169

    Google Scholar 

  • Sunohara N, Mukoyama M, Satoyoshi E (1984) Neoplastic angioendotheliomatosis of the central nervous system. J Neurol 231:14–19

    Google Scholar 

  • Wick MR, Banks PM, McDonald TJ (1981) Angioendotheliomatosis of the nose with fatal systemic dissemination. Cancer 48:2510–2517

    Google Scholar 

  • Wick MR, Scheithauer BW, Okazaki H, Thomas JE (1982) Cerebral angioendotheliomatosis. Arch Pathol Lab Med 106:342–346

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Depts. of Pathology and Anatomy, New York State College of Veterinary Medicine, 14853, Ithaca, NY, USA

    B. A. Summers & A. deLahunta

Authors
  1. B. A. Summers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. deLahunta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Summers, B.A., deLahunta, A. Cerebral angioendotheliomatosis in a dog. Acta Neuropathol 68, 10–14 (1985). https://doi.org/10.1007/BF00688949

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00688949

Key words

Search

Navigation