Summary
The amount of lipofuscin pigment within nerve cells of the nucleus basalis of Meynert and that of melanin pigment with nerve cells of locus ceruleus was measured in seven patients with Down syndrome, in 22 patients with Alzheimer's disease and in 18 controls ranging from 30 to 88 years of age. No significant differences in amount of either pigment in these cells at any age were noted between the patient groups and their age controls.
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References
Brain WR, Walton JN (1969) Clinical neurology. Oxford University Press, London
Critchley M (1933) Discussion on the mental and physical symptoms of the presenile dementias. Proc Roy Soc Med 26:1077–1079
Malamud N (1972) Neuropathology of organic brain syndromes associated with ageing. In: Gaitz CM (ed) Ageing and the brain. Plenum Press, New York, pp 63–67
Mann DMA, Sinclair KGA (1978) The quantitative assessment of lipofuscin pigment, cytoplasmic RNA and nucleolar volume in senile dementia. Neuropathol Appl Neurobiol 4:127–135
Mann DMA, Yates PO (1974a) Lipoprotein pigments. Their relationship to ageing in the human nervous system. I. The lipofuscin content of nerve cells. Brain 97:481–488
Mann DMA, Yates PO (1974b) Lipoprotein pigments. Their relationship to ageing in the human nervous system. II. The melanin content of pigmented nerve cells. Brain 97:489–498
Mann DMA, Yates PO (1979) The effects of ageing on the pigmented nerve cells of the human locus caeruleus and substantia nigra. Acta Neuropathol (Berl) 47:93–97
Mann DMA, Yates PO, Barton CM (1977) Melanin and RNA in cells of the human substantia nigra. J Neuropathol Exp Neurol 36:379–383
Mann DMA, Yates PO, Stamp JE (1978) Relationship of lipofuscin pigment to ageing in the human nervous system. J Neurol Sci 35:83–93
Mann DMA, Lincoln J, Yates PO, Stamp JE, Toper S (1980) Changes in monoamine containing neurones of the human CNS in senile dementia. Br J Psychiatry 136:533–541
Mann DMA, Yates PO, Hawkes J (1983) The pathology of the human locus caeruleus. Clin Neuropathol 2:1–7
Mann DMA, Yates PO, Marcyniuk B (1984) Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age from a continuum of pathological change. Neuropathol Appl Neurobiol (in press)
Poszonyi J, Gibson D, Zarfas DE (1963) Skeletal maturation in mongolism. J Paediatr 64:75–78
Price DL, Whitehouse PJ, Struble RG, Coyle JT, Clark AW, De Long MR, Cork LC, Hedreen JC (1982) Alzheimer's disease and Down syndrome. Proc NY Acad Sci 396:145–164
West CD (1979) A quantitative study of lipofuscin accumulation with age in normals and individuals with Down syndrome, phenylketonuria, progeria and transneuronal atrophy. J Comp Neurol 186:109–116
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Mann, D.M.A., Yates, P.O. & Marcyniuk, B. Relationship between pigment accumulation and age in Alzheimer's disease and Down syndrome. Acta Neuropathol 63, 72–77 (1984). https://doi.org/10.1007/BF00688473
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DOI: https://doi.org/10.1007/BF00688473