Acta Neuropathologica

, Volume 61, Issue 1, pp 27–35 | Cite as

Neuropathologic changes in suckling and weanling rats with pyrithiamine-induced thiamine deficiency

  • N. Horita
  • A. Okuno
  • Y. Izumiyama
Original Works


Pregnant and nursing Wistar rats were fed a thiamine-deficient diet, and their offspring were injected daily with pyrithiamine. The pathologic lesions in the suckling rats were examined at different times of development. There were distinct changes at 22 days of age, by which time the rats are weaned, and the morphogenesis of the cerebellum is almost completed. Before 22 days of age, there were no pathologic changes except for scattered petechial hemorrhages in the brain.

After 22 days of age, acute pathologic changes were observed, in decreasing order of severity, in the vestibular nuclei, inferior olivary nuclei, mammillary body, periventricular gray matter, thalamus, and quadrigeminal plates. The initial changes were swelling of postsynaptic dendrites and distension of the periaxonal space of myelinated axons in the parenchyma and ringshaped hemorrhages in the perivascular space. Pyrithiamine injections into the offspring of rats fed a thiamine-deficient diet probably induce disturbance of the electrolyte permeability of the neuronal excitable membrane, resulting in swelling of this element. These changes were followed by the infiltration of erythrocytes and plasma into the parenchyma and astrocytic swelling, which may be a secondary effect of neuronal changes on the rain vascular permeability.

Key words

Thiamine Development Wernicke's Encephalopathy Postsynaptic dendrite 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • N. Horita
    • 1
  • A. Okuno
    • 2
  • Y. Izumiyama
    • 1
  1. 1.Division of Ultrasructure and HistochemistryPsychiatric Research Institute of TokyoTokyoJapan
  2. 2.Dept. of PediatricsJikei University School of MedicineTokyoJapan

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