Summary
An immunohistochemical study was made of ten cases of asymptomatic and three cases of symptomatic Rathke's cleft cyst. The cysts in the asymptomatic cases had monolayer columnar or cuboidal epithelium. Within the epithelium, cells which were positive for at least one of the pituitary hormones were found. The rate of positive reactions for these six pituitary hormones was between 70% and 100%. In contrast, the cysts in the symptomatic cases had an epithelium which was partly stratified squamous and partly squamous epithelium, and none of the pituitary hormones were found in them. Therefore, when a Rathke's cleft cyst enlarges to the extent that clinical symptoms are produced, we consider that changes have already occurred in structure and function of the cyst epithelium. In addition, we believe there is a tendency for monolayer epithelia to undergo squamous metaplasia and for cells which are positive for pituitary hormones to change into non-granulated cells.
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Bryant WS (1916) Sensory elements in the human cerebral hypophysis. Anat Rec 11:25–27
Gillman T (1940) The incidence of ciliated epithelium and mucous cells in the normal Bantu pituitary. S Afr J Med Sci 5:30–40
Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577–580
Ikeda H, Niizuma H, Suzuki J, Sasano N (1986) Stereographic aspect of the developmental primordium of human pituitary gland — with special reference to the connection with the diencephalon. In: Yoshimura F, Gorbman A (ed) Pars distalis of the pituitary gland — Structure, function, regulation. Elsevier. Amsterdam New York Oxford, pp 17–19
Ikeda H, Suzuki J, Sasano N, Niizuma H (1988) The development and morphogenesis of the human pituitary gland. Anat Embryo 178:327–336
Shanklin (1951) The incidence and distribution of cilia in the human pituitary with a description of micro-follicular cysts derived from Rathke's cleft. Acta Anat 11:361–382
Steinberg GK, Koenig GH, Golden JB (1982) Symptomatic Rathke's cleft cysts. J Neurosurg 56:290–295
Yoshida J, Kobayashi T, Kageyama N, Kanzaki M (1977) Symptomatic Rathke's cleft cyst. Morphological study with light and electron microscopy and tissue culture. J Neurosurg 47:451–458
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Ikeda, H., Yoshimoto, T. & Suzuki, J. Immunohistochemical study of Rathke's cleft cyst. Acta Neuropathol 77, 33–38 (1988). https://doi.org/10.1007/BF00688240
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DOI: https://doi.org/10.1007/BF00688240