A study on the influence of papovavirus upon encephalitis caused by SSPE agent
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To investigate a possible interaction between the SSPE agent and papovaviruses, histopathological and statistical evaluations were made of encephalitis induced in hamsters by intracerebral inoculation with isolates from SSPE and PML patients, and with BK virus, alone or in combination.
With SSPE virus alone, hamster brains showed a reduction of susceptibility to encephalitis with increasing age. A modification of the pathology of SSPE encephalitis was observed after administration of the PML isolate or BK virus: encephalitis was either enhanced or inhibited depending on the time the papovaviruses were administered. A possible mechanism of interaction between SSPE and papovaviruses is briefly discussed.
Key wordsSubacute Sclerosing Panencephalitis (SSPE) Virus Papovavirus Virus Interaction Virus Encephalitis Progressive Multifocal Leucoencephalopathy (PML)
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- Albrecht, P., Schumacher, H. P.: Neurotropic properties of measles virus in hamsters and mice. J. infect. Dis.124, 86–93 (1971)Google Scholar
- Byington, D. P., Johnson, K. P.: Experimental subacute sclerosing panencephalitis in the hamster: Correlation of age with chronic inclusion cell encephalitis. J. infect. Dis.126, 18–26 (1972)Google Scholar
- Byington, D. P., Johnson, K. P.: Subacute sclerosing panencephalitis (SSPE) agent in hamsters. II. The neuropathology of acute and chronic infections. Exp. molec. Path.18, 345–356 (1973)Google Scholar
- Gardner, S. D., Field, A. M., Coleman, D. V., Hulme, B.: New human papovavirus (B. K.) isolated from urine after renal transplantation. Lancet1971 I., 1253–1257Google Scholar
- Girardi, A. J.: Personal communicationGoogle Scholar
- Koprowski, H., Barbanti-Brondano, G., Katz, M.: Interaction between papova-like virus and paramyxovirus in human brain cells: A hypothesis. Nature (Lond.)225, 1045–1047 (1970)Google Scholar
- Lehrich, J. R., Katz, M., Rorke, L. B., Barbanti-Brondano, G., Koprowski, H.: Subacute sclerosing panencephalitis. Encephalitis in hamsters produced by viral agents isolated from human brain cells. Arch. Neurol. (Chic.)23, 97–102 (1970)Google Scholar
- Levy, N. L.: Synergism between polyoma and inactivated Sendai virus in human astrocytes, fibroblasts and HeLa cells. J. Neuropath. exp. Neurol.31, 639–644 (1972)Google Scholar
- ter Meulen, V., Katz, M., Käckell, Y. M., Barbanti-Brondano, G., Koprowski, H., Lennette, E. H.: Subacute sclerosing panencephalitis. In vitro characterization of viruses isolated from brain cells in culture. J. infect. Dis.126, 11–17 (1972)Google Scholar
- Walker, D. L., Padgett, B. L., ZuRhein, G. M., Albert, A. E., Marsh, R. F.: Human papovavirus (JC): Induction of brain tumors in hamsters. Science181, 674–676 (1973)Google Scholar
- Weiner, L. P., Herndon, R. M., Narayan, O., Johnson, R. T., Shah, K., Rubinstein, L. J., Priziosi, T. J., Conley, F. K.: Isolation of virus related to SV 40 from patients with progressive multifocal leucoencephalopathy. New Engl J. Med.286, 385–390 (1972)Google Scholar
- Weiner, L. P., Narayan, O., Penny, J. B., Jr., Herndon, R. M., Ferigna, E. R., Tourtellotte, W. M., Johnson, R. T.: Papovavirus of JC type in progressive multifocal leucoencephalopathy. Arch. Neurol. (Chic.)29, 1–3 (1973)Google Scholar