Summary
A group of 5 selected malignant meningiomas was studied in relation to the incidence and morphology of the mitoses. Beside a high mitoric rate many structural chromosomal abnormalities were observed. In agreement with other malignant oncotypes previously studied, the authors suggest that atypical mitoses together with a tissue and cytological undifferentiation may be assumed to be an important prognostic criterium for meningiomas.
The problem of malignancy in meningiomas has not been, so far, satisfactorily resolved, so that, in our opinion, the definition of even minimal details may be of some interest. For example, as it clearly appears from reviewing the literature on this subject, no particular attention has been paid to the mitotic features. Referring to previous studies on the mitotic abnormalities in different malignant cerebral oncotypes, the authors aimed to examine the various mitotic aspects in a limited group of tumors selected on the basis of clinical and histological malignancy.
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References
Barka, T., Anderson, P. J.: Histochemistry. Theory, practice and bibliography. New York-Evanston-London: Hoeber Med. Div. Harper and Row 1963
Cammermeyer, J.: The life history of the microglial cell: A light microscopic study. Neurosci. Res.3, 43–129 (1970)
Cognazzo, A., Fabiani, A., Monticone, G. F., Schiffer, D.: Sulla frequenza e morfologia delle mitosi e dei cosidetti nuclei linfocito-simili in alcuni oncotipi cerebrali. Boll. Soc. ital. Biol. sper.43, 1343–1344 (1967)
Fabiani, A., Monticone, G. F., Schiffer, D.: Histochemical study of hydrolytic enzymes in meningiomas. Psychiat et Neurol. (Basel)154, 95–105 (1967)
Jellinger, K., Slowik, F.: Histological subtypes and prognostic problems in meningiomas. J. Neurol.208, 279–298 (1975)
Pearse, A. G. E.: Histochemistry. Theoretical and applied. London: Churchill 1968–1972
Sandritter, W., Kiefer, G., Rick, W.: Über die Stöchiometrie von Gallocyaninchromalaun mit Desoxyribonukleinsäure. Histochemie3, 315–340 (1963)
Schiffer, D., Fabiani, A., Monticone, G. F., Cognazzo, A.: On the nature of the lymphocyte-like cells of medulloblastomata. Acta neuropath. (Berl.)6, 290–297 (1966)
Schiffer, D., Fabiani, A.: Photosensitization effects on the solubility of acid phosphatase in nervous tissue. Histochemie26, 89–92 (1971)
Schümmelfeder, R., Krogh, R. E., Ebschner, K. J.: Färbungsanalysen zur Acridine-orange-Fluorochromierung. Vergleichende histochemische und fluorescenzmikroskopische Untersuchungen am Kleinhirn der Maus mit Acridinorange und Gallocyanin-Chromalaun-Färbungen. Histochemie1, 1–28 (1958)
Skullerud, K., Löken, A. C.: The prognosis in meningiomas. Acta neuropath. (Berl.)29, 337–344 (1974)
Smart, I., Leblond, C. P.: Evidence for division transformations of neuroglia cells in the mouse brain, as derived from radiography after injection of thimidine-H3. J. comp. Neurol.116, 349–366 (1961)
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Partially supported by Consiglio Nazionale delle Ricerche (CNR), Italy. Contr. No CT76.01222.04
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Fabiani, A., Trebini, F., Favero, M. et al. The significance of atypical mitoses in malignant meningiomas. Acta Neuropathol 38, 229–231 (1977). https://doi.org/10.1007/BF00688070
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DOI: https://doi.org/10.1007/BF00688070