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Aqueductal lesions in 6-aminonicotinamide-treated suckling mice

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Summary

Suckling mice which received a single intraperitoneal injection of 6-aminonicotinamide on the 5th postnatal day, consistently developed hydrocephalus. During the early stages of hydrocephalus (7–9 days after injection), aqueductal lesions were characterized by edematous ependymal and subependymal cells, and spongy changes in the periaqueductal area, which resulted in aqueduct stenosis. Later stages (after 20 days post-injection) showed that these edematous changes totally subsided, leaving an obliterated aqueduct which was similar to that of human congenital hydrocephalus. At the completely obliterated area, ultrastructural investigation disclosed a normal-looking neuropil but no aqueductal lumen. In the remaining ependymal cell, increased intermediate filaments and lipid droplets occurred. These data suggest that acute ependymal cell degeneration during the perinatal period may result in the profile of aqueduct “agenesis” in human congenital hydrocephalus.

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Authors and Affiliations

  1. Division of Ultrastructural Research, National Center for Nervous, Mental and Muscular Disorders, 4-1-4, Ogawa-Higashi-Machi, 187, Kodaira, Tokyo, Japan

    H. Aikawa

  2. Departments of Pathology (Neuropathology) and Neuroscience, the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York

    H. Aikawa, S. Kobayashi & K. Suzuki

Authors
  1. H. Aikawa
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  2. S. Kobayashi
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  3. K. Suzuki
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Supported in part by research grants NS-03356, NS-10803 from NINCDS, USPHS

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Aikawa, H., Kobayashi, S. & Suzuki, K. Aqueductal lesions in 6-aminonicotinamide-treated suckling mice. Acta Neuropathol 71, 243–250 (1986). https://doi.org/10.1007/BF00688046

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  • DOI: https://doi.org/10.1007/BF00688046

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