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Intranuclear inclusions in a case of Creutzfeldt-Jakob disease

An ultrastructural study

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Summary

Two types of intranuclear inclusions were described in a brain biopsy from a patient with Creutzfeldt-Jakob disease. The first type of intranuclear inclusion was papova virus-like and was observed within 20% of the nuclei of all astrocytes and neurons examined. The particles measured 32 nm in diameter and consisted of a dense core surrounded by a multilayered shell. The second type of intranuclear inclusion was a granulo-fibrillar nuclear body found within the nuclei of astrocytes and neurons. The possible significance of these inclusions to the etiology of Creutzfeldt-Jakob disease is discussed.

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Authors and Affiliations

  1. Department of Pathology, University of Arizona College of Medicine and University Hospital, 85724, Tucson, Arizona, USA

    Claire M. Payne & William A. Sibley

  2. Department of Neurology, University of Arizona College of Medicine and University Hospital, Tucson, Arizona

    Claire M. Payne & William A. Sibley

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  1. Claire M. Payne
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  2. William A. Sibley
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Payne, C.M., Sibley, W.A. Intranuclear inclusions in a case of Creutzfeldt-Jakob disease. Acta Neuropathol 31, 353–361 (1975). https://doi.org/10.1007/BF00687930

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  • DOI: https://doi.org/10.1007/BF00687930

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