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Chromatolysing spinal neurons in the chick following tricresylphosphate (TCP) intoxication

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Summary

Chromatolytic neurons in the anterior and posterior horns at lumbar level of the chick's spinal cord are found after oral application of 0.22 cc/kg of a mono-, ortho ester of TCP.

These neuronal changes are accompanied by ascending fibre degeneration.

It is suggested that the neuronal and tract degeneration observed are causally related, thus bringing the morphology of the TCP neurotoxicity in line with Wallerian degeneration.

Zusammenfassung

In den lumbalen Vorder- und Hinterhörnern des Hühner-Rückenmarkes sind nach oraler Verabreichung von 0,22 cc/kg eines TCP-Mono-ortho-Esters chromatolytische Neurone zu finden.

Diese neuronalen Läsionen sind von aufsteigender Faserdegeneration begleitet.

Es wird vermutet, daß die beobachteten Nervenzell- und Strangdegenerationen in kausaler Beziehung stehen, wonach die Morphologie der Neurotoxicität von TCP zur Wallerschen Degeneration Beziehungen besitzt.

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  1. Institut für Histologie und experimentelle Neuroanatomie, Kreuzring 36, Göttingen, Germany

    H. H. Janzik & P. Glees

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  1. H. H. Janzik
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  2. P. Glees
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Janzik, H.H., Glees, P. Chromatolysing spinal neurons in the chick following tricresylphosphate (TCP) intoxication. Acta Neuropathol 6, 303–306 (1966). https://doi.org/10.1007/BF00687861

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  • DOI: https://doi.org/10.1007/BF00687861

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