Summary
In order to elucidate the nature of the lymphocyte-like nuclei in medulloblastomata, 46 tumours have been histologically and histochemically investigated. 3 types of these nuclei can be distinguished: granule cells of the cerebellum included in the tumour; nuclei of necrotic type grouped in small foci; and nuclei of nonnecrobiotic type. The latter are considered to be the result of pathological processes affecting mitoses and to represent the different stages of these processes. In this regard the presence of abnormal mitoses in medulloblastoma is emphasized, as they must be expected in a rapidly growing tumour.
Zusammenfassung
Um das Wesen der Lymphocyten-ähnlichen Kerne im Medulloblastom aufzuklären, wurden 46 Tumoren histologisch und histochemisch untersucht. Es lassen sich 3 Typen dieser Kerne unterscheiden: im Tumor eingeschlossene cerebellare Körnerzellen, Kerne vom nekrotischen Typ, die in kleinen Herden gehäuft auftreten, und Kerne vom nicht-nekrotischen Typ. Letztere werden mit pathologischen, die Mitosen beeinflussenden Vorgängen in Beziehung gebracht und dürften verschiedene Stadien derselben darstellen. Das Auftreten pathologischer Mitosen, wie es bei einem rasch wachsenden Tumor zu erwarten ist, wird in diesem Zusammenhang hervorgehoben.
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Schiffer, D., Fabiani, A., Monticone, G.F. et al. On the nature of the lymphocyte-like cells of medulloblastomata. Acta Neuropathol 6, 290–297 (1966). https://doi.org/10.1007/BF00687859
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DOI: https://doi.org/10.1007/BF00687859