Summary
A case of multifocal malignant glioma of the brain in a 67-year-old male is presented. The main neoplastic focus occupied both the frontal lobes and the anterior portion of corpus callosum. Numerous small neoplastic foci, so-called „satellite metastases” surrounded the main neoplastic masses. There was a second neoplastic focus situated in the basal portion of the pons. This showed the histological features of the anaplastic glioma. No direct connection between two neoplastic foci was shown on serial section through the midbrain. There were „blastomatoid” glial cells seen in the unchanged nervous tissue of the pons and medulla, they were single or grouped in small clusters. The morphology of the pontine neoplasm and the presence of above mentioned „blastomatoid” astrocytes widespread throughout the brain stem suggested that we were dealing with primary multifocal growth of the glial tumour.
Résumé
On a presenté un cas de la tumeur neoplasmique, notamment un gliome maligne multiloculaire chez un malade âgé de 67 ans. Le foyer principal se trouve dans la région frontale bilateralement et infiltre la moitié anterieur du corps calleux. Ce foyer est entouré des petits foyers secondaires dits «métastases satellitaire». L'image microscopique de la tumeur correspond rélativement aux caractères d'un glioblastome multiforme.
Dans la base du pont on a trouvé un autre foyer aux trais d'un gliome anaplastique, indepandant de la lésion principale.
A part de cette seconde tumeur on a pu constater de nombreuses cellules blastomatiques parsemées parmi les fibres pontines, tantôt iselées, tantôt en petits groupe cellulaires.
Les caractères morphologiques de la tumeur pontine et la présence des cellules blastomatiques isolées suggère qu'il s'agit dans ce cas d'un processus multifocal
L'auteur discute la possibilité d'une gliopathie généralisée.
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Mossakowski, M.J. Multifocal malignant glioma of the brain. Acta Neuropathol 1, 533–537 (1962). https://doi.org/10.1007/BF00687355
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DOI: https://doi.org/10.1007/BF00687355