Abstract
The subjects were 35 patients with unresectable hepatocellular carcinoma. The patients were divided into a transcatheter arterial embolization group (TAE group, 18 cases) and a combination therapy group receiving both TAE and percutaneous ethanol injection therapy (TAE+PEIT group, 17 cases). The 50% survival period was 21.1 months for the TAE group and 37.8 months for the TAE+PEIT group (P<0.05). The longest survival period in the TAE group was 89 months. In the TAE+PEIT group, one patient has survived for 59 months. The actuarial 1-, 2-, and 3-year survival rates for the TAE group were 82%, 45%, and 22%, respectively. For the TAE+PEIT group the rates were 83%, 64%, and 64%, respectively. The TAE+PEIT group showed a significantly higher survival rate in the 895-to 1.074-day period as compared with the TAE groupP<0.05). Overall, the survival rate tended to be higher in the TAE-PEIT group (P<0.1). The therapeutic responses of tumors were measured by the maximal reduction rate within 6 months of TAE and PEIT. In the TAE group, a PR was seen in only four cases. In the TAE+PEIT group, CRs and PRs were achieved significantly more frequently than in the TAE group. When the patients were divided into a responder group (CR, PR, and MR) and a nonresponder group (NC and PD), survival was significantly longer in the responder group. The findings of the present study suggest that the combination therapy was useful for improving the survival of patients with unresectable hepatocellular carcinoma.
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Ebara M. Ohto M, Sugiura N, Kia K, Yoshikawa M, Okuda K, Kondo F, Kondo Y (1990) Percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Study of 95 patients. J Gastrohepatol 5: 616
Fujimoto T (1988) The experimental and clinical studies of percutaneous ethanol injection therapy (PEIT) under ultrasonography for small hepatocellular carcinoma (in Japanese). Acta Hepatol Jpn 29: 52
Hasuike Y, Okamura J, Furukawa J, Naoi M, Takata N, Maruyama H, Kimuta M, Yayoi E, Oi H, Okamoto S, Monden M, Mori T, Sakurai M (1992) Efficacy of combination treatment — TAE with Adriamycin and ethanol — for hepatocellular carcinoma. Cancer Chemother Pharmacol 31 [Suppl I]: S 30
Liver Cancer Study Group of Japan (1988) Survey and follow-up study of primary liver cancer in Japan — 8th report (in Japanese). Shinko-insatsu, Kyoto, p 63
Liver Cancer Study Group of Japan (1988) The general rules for the clinical and pathological study of primary liver cancer. Jpn J Surg 19: 98
Liver Cancer Study Group of Japan (1991) Survey and follow-up study of primary liver cancer in Japan — 9th report (in Japanese). Shinko-insatsu, Kyoto, p 104
Livraghi T, Salmi A, Bolondi L, Malin G, Arienti V, Monti F, Vettori C (1988) Small hepatocellular carcinoma: percutaneous alcohol injection — results in 23 patients. Radiology 168: 313
Nakamura H, Tanaka T, Hori S, Yoshioka H, Kuroda C, Okamura J, Sakurai M (1983) Transcatheter embolization of hepatocellular carcinoma: assessment of efficacy in cases of resection following embolization. Radiology 147: 401
Sakurai M, Okamura J, Kuroda C, Yamada T (1986) Active inflammatory change of the liver as a cause of postoperative hepatic failure. Jpn J Surg 16: 398
Shiina S, Yasuda H, Muto H, Tagawa K, Unuma T, Ibukuro K, Inoue Y, Takanashi R (1987) Percutaneous ethanol injection in the treatment of liver neoplasms. AJR 149: 949
Shiina S, Tagawa K, Unuma T, Fujino H, Uta Y, Niwa Y, Hata Y, Komatsu Y, Shiratori Y, Terano A, Sugimoto T (1990) Percutaneous ethanol injection therapy of hepatocellular carcinoma AJR 155: 1221
Sugihara S, Kojiro M, Nakashima T (1985) Ultrastructural study of hepatocellular carcinoma with replacing growth pattern. Acta Pathol Jpn 35: 549
Sugiura N, Takara K, Ohto M, Okuda K, Hirooka N (1983) Percutaneous intratumoral injection of ethanol under ultrasound imaging for treatment of small hepatocellular carcinoma (in Japanese). Acta Hepatol Jpn 24: 920
Takashimizu I, Yamanaka A, Takenaga T, Yamada M, Sasabe M, Tamura Y, Yamamoto N, Kurosawa H, Fujimoto H, Ohkusa T, Nakamura R, Kuyama Y, Okayasu I (1988) The necrotizing effect of the direct injection of anhydrous ethanol on the liver in the rabbit (in Japanese). Jpn J Gastroenterol 85: 886
Tanaka K, Nakamura S, Numata K, Okazaki H, Endo O, Inoue S, Takamura Y, Sugiyama M, Ohaki Y (1992) Hepatocellular carcinoma: treatment with percutaneous ethanol injection and transcatheter arterial embolization. Radiology 185: 457
Yamada R, Sato M, Nomura S, Nakatsuka H, Yamada T (1985) Transcatheter arterial embolization in hepatocellular carcinoma. J Jpn Soc Cancer Ther 20: 1627
Yoshimi F, Nagao T, Inoue S, Kawano N, Muto T, Gunji T, Ohnishi S, Imawari M (1992) Comparison of hepatectomy and transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma: necessity for prospective randomized trial. Hepatology 16: 702
Yune HY, Klatte EC, Richmond BD, Rabe FE (1982) Absolute ethanol in thrombotherapy of bleeding esophageal varices. AJR 138: 1137
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Tateishi, H., Kinuta, M., Furukawa, J. et al. Follow-up study of combination treatment (TAE and PEIT) for unresectable hepatocellular carcinoma. Cancer Chemother. Pharmacol. 33 (Suppl 1), S119–S123 (1994). https://doi.org/10.1007/BF00686682
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DOI: https://doi.org/10.1007/BF00686682