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Suramin: an anticancer drug with unique biological effects

  • Review
  • Suramin, Anticancer Drug, Biological Effects
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Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Conclusion and perspectives

At present the primary mechanism(s) of suramin action is not known. It is possible that several of the factors mentioned in this review are of importance for the drug's antitumor activity and even that different mechanisms are of importance for different cell types. An improved knowledge about the relative importance of the many different biologic effects of suramin is essential to the establishment of better drug combinations and to the development of suramin derivatives with an improved therapeutic index. The development and characterization of suramin-resistant cells would be a major step in this direction.

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Authors and Affiliations

  1. Department of Molecular Pharmacology, INSERM U 140, CNRS URA 147, Institut Gustave Roussy, rue Camille Desmoulins, F-94805, Villejuif Cedex, France

    Annette Kragh Larsen

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  1. Annette Kragh Larsen
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Larsen, A.K. Suramin: an anticancer drug with unique biological effects. Cancer Chemother. Pharmacol. 32, 96–98 (1993). https://doi.org/10.1007/BF00685609

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  • DOI: https://doi.org/10.1007/BF00685609

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