Summary
The pathogenesis, histopathology and, to a limited extent, the histochemistry of iron in the CSF and the CNS are discussed in the light of post-mortem observations made on a patient who had presented himself with signs of a midline posterior fossa tumour and with pains in the neck and the lower limbs. He showed (1) a haemorrhagic pinealoma with meningeal siderosis; (2) an arachnoidal cerebellar cyst with iron pigment in the wall and xanthochromic fluid; (3) siderosis of CNS, especially of cerebellar, border zones; (4) siderosis of spinal root sheaths and meninges; (5) siderotic necrosis of spinal ganglia, with vascular, histiocytic and inflammatory reactions; and (6) siderosis of spinal nerve, especially of the perineurium. The role of CSF as a diffusing agent, and of diffusible toxic ferric micelles, in the production of these changes is stressed.
Zusammenfassung
An Hand der autoptischen Untersuchungen an einem Patienten, der Zeichen eines Mittellinientumors der hinteren Schädelgrube sowie Schmerzen im Nacken und in den unteren Gliedmaßen geboten hatte, werden Pathogenese, Histopathologie und in beschränktem Maße auch die Histochemie des Eisens im Liquor und im ZNS diskutiert. Folgende Befunde wurden erhoben: 1. ein hämorrhagisches Pinealom mit Meningealsiderose; 2. eine arachnoidale Kleinhirncyste mit xanthochromem Inhalt und mit Eisenpigment in den Wänden; 3. Siderose der Randzonen des ZNS, besonders des Kleinhirns; 4. Siderose der spinalen Wurzelscheiden und der Meningen; 5. siderotische Nekrosen der Spinalganglien mit entzündlichen Gefäßreaktionen; 6. schließlich Siderose der Spinalnerven, besonders des Perineuriums. Die Rolle des Liquors als diffusibles Agens und der diffusiblen toxischen Eisenmicellen beim Zustandekommen dieser Veränderungen wird betont.
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Dastur, D.K., Sinh, G. Toxic iron and the nervous system. Acta Neuropathol 2, 161–176 (1962). https://doi.org/10.1007/BF00685173
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DOI: https://doi.org/10.1007/BF00685173