Summary
Particles resembling virions observed in brain biopsies of two patients with Creutzfeldt-Jakob disease were located almost exclusively in the cytoplasm of the astrocytes which were swollen and showed accumulations of glia fibres, sometimes the cell bodies of the astrocytes were destroyed.
Zusammenfassung
Virusähnliche Partikel wurden in Gehirnbiopsien von zwei Patienten mit Creutzfeldt-Jakobscher Krankheit beobachtet. Diese Partikel fanden sich fast ausschließlich im Cytoplasma von Astrocyten, die eine Konzentration von Gliafilamenten, Schwellung oder sogar Desintegration zeigten.
References
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Bots, G.T.A.M., de Man, J.C.H. & Verjaal, A. Virus-like particles in brain tissue from two patients with Creutzfeldt-Jakob disease. Acta Neuropathol 18, 267–270 (1971). https://doi.org/10.1007/BF00685073
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DOI: https://doi.org/10.1007/BF00685073