Summary
Particles resembling virions observed in brain biopsies of two patients with Creutzfeldt-Jakob disease were located almost exclusively in the cytoplasm of the astrocytes which were swollen and showed accumulations of glia fibres, sometimes the cell bodies of the astrocytes were destroyed.
Zusammenfassung
Virusähnliche Partikel wurden in Gehirnbiopsien von zwei Patienten mit Creutzfeldt-Jakobscher Krankheit beobachtet. Diese Partikel fanden sich fast ausschließlich im Cytoplasma von Astrocyten, die eine Konzentration von Gliafilamenten, Schwellung oder sogar Desintegration zeigten.
This is a preview of subscription content, log in via an institution to check access.
References
Gibbs, C. J., Jr., Gajdusek, D. C., Asher, D. M., Alpers, M. P., Beck, E., Daniel, P. M., Matthews, W. B.: Creutzfeldt-Jakob disease (spongiforme encephalopathy) transmission to the chimpanzee. Science161, 388–389 (1968).
Foley, J. M., Denny-Brown, D.: Subacute progressive encephalopathy with bulbar myoclonus. J. Neuropath. exp. Neurol.16, 133–136 (1957).
Silberman, J., Cravioto, H., Feigin, I. Cortico-striatal degeneration of the Creutzfeldt-Jakob type. J. Neuropath. exp. Neurol.20, 105–118 (1961).
Vernon, M. L., Horta-Barbosa, L., Fuccillo, D. A. Sever, J. L., Baringer, J. R., Birnbaum, G.: Virus-like particles and nucleoprotein-type filaments in brain tissue from two patients with Creutzfeldt-Jakob disease. LancetI, 1970, 964–966.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bots, G.T.A.M., de Man, J.C.H. & Verjaal, A. Virus-like particles in brain tissue from two patients with Creutzfeldt-Jakob disease. Acta Neuropathol 18, 267–270 (1971). https://doi.org/10.1007/BF00685073
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00685073