Summary
Selective necrosis of the granular layer of the cerebellum was induced in 14 of 25 rats by subcutaneous injections of thiophen.
Pyknosis of the granule cell nuclei can be seen before any alteration in the cytoplasmatic oxidative enzymes or acid phosphatases.
After the termination of the thiophen injections there is a temporary fall in the NADH-tetrazolium reductase in the Purkinje cells. This may be due to a transneuronal influence of the altered granule cells.
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Albrechtsen, R., Jensen, H. Histochemical investigation of thiophen necrosis in the cerebellum of rats. Acta Neuropathol 26, 217–223 (1973). https://doi.org/10.1007/BF00684431
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DOI: https://doi.org/10.1007/BF00684431