Der Effekt Peroraler Antikonzeptionsmittel auf den in vitro-Glucosestoffwechsel des Endometrium

Summary

O₂-upptake, formation of lactat in aerobic and anaerobic conditions and conversion of glucose-C-6 to CO₂ was measured in 32 endometrial biopsies after oral administration of combination preparationes and compared with the same parameters in 42 biopsies from normal menstrual cycles. The results showed a reduction of the endometrial oxygen consumtion to almost half the value after oral contraceptives. The endogenous aerobic and anaerobic lactic formation increased hightly significantly in the controlgroup from the proliferative to the secretory phase. When influenced by the combination preparationes the lactic formation was only slightly increased in the first part of the cycle but was very low during the second phase.

In the normal endometrium the conversion of glucose-C-6 to CO₂ is gradually lowered when passing from proliferative to secretory phase. In the hormonally treated endometrium the conversion values are low in the beginning of the cycle and moderatly increased in the later part. The courves of both the lactic formation and glucose-C-6-conversion during the menstrual cycle in the treated group are thus inverted compared with the courves from the control group.

The ratio of endometrial aerobic/anaerobic metabolism is the same during the first phase of the hormonal treatment as in the secretory phase of the normal cycle. These results indicate that the changed endometrial metabolism may play a part in the anticonceptional effect of these drugs.