Abstract
Indolines are amidomethylated in the 6 position in acidic media. N-Acetylation changes the orientation to give the 5-substituted isomers. Dehydrogenation of the reaction products and subsequent hydrolysis make it possible to obtain 5-or 6-aminomethylindoles.
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See [1] for communication XLII.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1339–1342, October, 1975.
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Kost, A.N., Yudin, L.G. & Abdullaev, M. Chemistry of indole XLIII. New synthesis of benz(aminomethyl)indoles. Chem Heterocycl Compd 11, 1144–1147 (1975). https://doi.org/10.1007/BF00667610
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DOI: https://doi.org/10.1007/BF00667610