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Limits of cyclodextrin application in oral drug preparations

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Abstract

Cyclodextrins are applied to facilitate formulation problems, to improve stability and bioavailability. Following factors are determining whether or not cyclodextrins can be applied in oral pharmaceutical preparations:

  • - properties of the selected CD: solubility, price, specific catalytic properties,

  • - the drug to be complexed: molecular weight, polarity, solubility,

  • - drug dose

  • - solubility properties of the complex and the “super solubility” /temporary over-saturation/

  • - complex stability and possibility to shift the dissociation equilibrium toward the appropriate direction

  • - legislative procedures

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Authors and Affiliations

  1. Biochem. Res. Laboratory of CHINOIN Pharm.-Chem. Works, 1026 Endrődi S., 38-40, Budapest, Hungary

    J. Szejtli

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  1. J. Szejtli
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Szejtli, J. Limits of cyclodextrin application in oral drug preparations. Journal of Inclusion Phenomena 2, 487–501 (1984). https://doi.org/10.1007/BF00662215

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  • DOI: https://doi.org/10.1007/BF00662215

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