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Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions

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Abstract

Complex formation of α-, β-, and γ-cyclodextrins with sulfasalazine in biologically relevant buffer solutions (pH 1.2 and 7.4) was studied. Formation of inclusion complexes of 1 : 1 stoichiometry between the drug and cyclodextrins was revealed. The ionization state of sulfasalazine more strongly affects the complex formation than does the structure of cyclodextrins. Compared with a neutral molecule, sulfasalazine anionic species forms with cyclodextrins more stable complexes, which are essentially stabilized by possible surface interactions.

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Authors and Affiliations

  1. G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, ul. Akademicheskaya 1, Ivanovo, 153045, Russia

    D. Yu. Kuranov, E. S. Chibunova, T. V. Volkova & I. V. Terekhova

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  1. D. Yu. Kuranov
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  2. E. S. Chibunova
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  3. T. V. Volkova
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  4. I. V. Terekhova
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Corresponding author

Correspondence to D. Yu. Kuranov.

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Original Russian Text © D.Yu. Kuranov, E.S. Chibunova, T.V. Volkova, I.V. Terekhova, 2016, published in Rossiiskii Khimicheskii Zhurnal, 2016, Vol. 60, No. 1, pp. 55–61.

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Kuranov, D.Y., Chibunova, E.S., Volkova, T.V. et al. Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions. Russ J Gen Chem 88, 1325–1330 (2018). https://doi.org/10.1134/S1070363218060439

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  • DOI: https://doi.org/10.1134/S1070363218060439

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