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[3H]-Domperidone labels only a single population of receptors which convert from high to low affinity for dopamine in rat brain

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Summary

Dopamine recognized and competed for a single population of [3H]-domperidone-binding sites in rat striatum and olfactory tubercle when tested in the presence of sodium ions and guanine nucleotide [Gpp(NH)p]. In the absence of Na+ and Gpp(NH)p, however, dopamine recognized two components of [3H]-domperidone binding. Thus, [3H]-domperidone labelled only a single population of dopamine receptors (type D2) which fully converted from high to low affinity for dopamine. These results agree with those found previously using [3H]-spiperone and [3H]-YM-09151-2.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Medical Sciences Building, University of Toronto, M5S 1A8, Toronto, Canada

    Dimitri Grigoriadis & Philip Seeman

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  1. Dimitri Grigoriadis
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  2. Philip Seeman
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Grigoriadis, D., Seeman, P. [3H]-Domperidone labels only a single population of receptors which convert from high to low affinity for dopamine in rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 332, 21–25 (1986). https://doi.org/10.1007/BF00633192

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  • DOI: https://doi.org/10.1007/BF00633192

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