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Synthesis of 1,4,7,7-tetramethylbicyclo[2.2.1]hept-exo-2-ylacylamines

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Abstract

A procedure has been developed for the selective preparation of 2-methylisoborneol by the action of methyllithium on camphane. It has been shown that the interaction of 2-methylisoborneol with aceto- and benzonitriles in the presence of sulfuric acid gives, as the result of a rearrangement of the carbon skeleton, high yields of the corresponding 1,4,7,7-tetramethylbicyclo[2.2.1]hept-exo-2-ylacylamines, which possess an anticataleptic action.

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Authors
  1. N. G. Kozlov
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  2. L. A. Popova
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  3. V. A. Knizhnikov
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Additional information

Institute of Physical Organic Chemistry, Belarus Academy of Sciences, Minsk. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 719–723, November–December, 1994.

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Kozlov, N.G., Popova, L.A. & Knizhnikov, V.A. Synthesis of 1,4,7,7-tetramethylbicyclo[2.2.1]hept-exo-2-ylacylamines. Chem Nat Compd 30, 666–668 (1994). https://doi.org/10.1007/BF00630598

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  • DOI: https://doi.org/10.1007/BF00630598

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