Abstract
Pregnant sheep inoculated withAspergillus fumigatus conidia developed precipitating and latex agglutinating antibodies to mycelial antigens. The titres of these tended to be higher in those animals developing placental or fetal infection than in those which did not. The concentrations of total serum proteins and of albumin,α, β andγ globulins did not show any consistent changes which could be related to abortion or placental infection. Lymphocyte transformation tests on whole blood showed significant responses to phytohaemagglutinin but not toA. fumigatus antigens.
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Ainsworth, G.C. & P.K.C. Austwick. 1959. In: Fungal Diseases of Animals. Commonwealth Bureau of Animal Health; Farnham Royal, Slough.
Amos W.M.G. 1970. The extraction of fungal antigens and their use in serological tests as an aid to the diagnosis of bronchial disorders. J. med. Lab. Technol. 27: 18–32.
Ciupercescu, D.D. 1977. Dynamics of serum immunoglobulin concentrations in sheep during pregnancy and lactation. Res. vet. Sci., 22: 23–27.
Corbel, M. J. 1972. Production of antibodies to placental antigens by pregnant ewes experimentally infected with Aspergillus fumigatus. Br. Vet. J. 138: 44–46.
Corbel, M.J., & C.A. Day. 1977. Examination of the immunoglobulin classes involved in the serological response of pregnant sheep to Aspergillus fumigatus. Sabouraudia, 16:23–33.
Corbel, M.J. & S.M. Eades. 1977. Examination of the effect of age and acquired immunity on the susceptibility of mice to infection with Aspergillus fumigatus. Mycopathologia, 60: 79–85.
Corbel, M.J., C.A. Pepin & P.G. Millar, 1973. The serological response to Aspergillus fumigatus in experimental mycotic abortion in sheep. J. med. Microbiol. 6: 539–548.
Cysewski, S.J., & A.C. Pier, 1968. Mycotic abortion in ewes produced by Aspergillus fumigatus: pathologic changes. Am. J. Vet. Res. 29: 1135–1151.
Day, C.A., & M.J. Corbel, 1974. Haematological changes associated with Aspergillus fumigatus infection in experimental mycotic abortion of sheep. Br. J. exp. Path. 55: 352–362.
Downey, R.S. In: Veterinary Physiology. Ed. J.W. Phillis. pp. 277–293. Wright-Scientechnicon, Bristol.
Han, T. & J. Pauly, 1972. Simplified whole blood method 64 for evaluating in vitro lymphocyte reactivity of laboratory animals. Clin. exp. Immunol. 11: 137–142.
Hugh-Jones, M.E. & P.K.C. Austwick, 1967. Epidemiological studies in bovine mycotic abortion. I. The effect of climate on incidence. Vet. Rec. 81: 273–276.
Pepin, G.A., P.G. Millar & D.J.W. Cole, 1979. Observations on the susceptibility of pregnant sheep to intrauterine infection by Aspergillus fumigatus conidia injected intravenously. To be published.
Pier, A.C., S.J. Cysewski & J.L. Richard, 1972. Mycotic abortion in ewes produced by Aspergillus fumigatus: Intravascular and intra-uterine inoculation. Am. J. vet. Res. 33: 349–356.
Thurston, J.R., S.J. Cysewski, A.C. Pier & J.L. Richard, 1972. Precipitins in serums from sheep infected with Aspergillus fumigatus. Am. J. vet. Res. 33: 929–933.
Wood, W.A. & M.J. Corbel, 1973. Concentrations of bovine serum protein classes in relation to reactivity in serological tests for brucellosis. J. comp. Path. 83: 143–150.
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Corbel, M.J., Day, C.A. & Cole, D.J.W. Examination of the relationship between pathological changes, immunological response and serum protein concentrations in pregnant sheep inoculated with Aspergillus fumigatus. Mycopathologia 71, 53–64 (1980). https://doi.org/10.1007/BF00625315
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DOI: https://doi.org/10.1007/BF00625315