Summary
Reaction of [MCl2(H4Y)] or (H6Y)[MCl4] compounds (M = Pd or Pt; Y = EDTA, PDTA or CDTA) with guanine (Gu-H) in 0.5 M HCl yields new complexes MCl2(Gu-H)(H2O which have been characterized by elemental analyses in conjunction with electronic, i.r. and n.m.r. spectra. A dimeric structure with two bridging chloride ligands, including coordination of guanine through atom N(9), is proposed for both compounds.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- EDTA:
-
1,2-diaminoethane-N,N,N′,N′-tetraacetate
- PDTA:
-
1,2-diaminopropane-N,N,N′,N′-tetraacetate
- CDTA:
-
trans-1,2-diaminocyclohexane-N,N,N′,N′-tetraacetate
- Gu-H:
-
guanine
- 9-EtGu-H:
-
9-ethylguanine
References
H. Sigel (Ed.),Metal Complexes as Anticancer Agents, M. Dekker, New York (1980).
P. J. Stone, A. D. Kelman and F. M. Sinex,Nature, 251, 736 (1974).
G. L. Cohen, J. A. Ledner, W. R. Bauer, H. M. Ushay, C. Caravana and S. J. Lippard,J. Am. Chem. Soc., 102, 2487 (1980).
T. D. Tullius and S. J. Lippard,J. Am. Chem. Soc., 103, 4620 (1981).
T. J. Kistenmacher, J. D. Orbell and L. G. Marzilli,A. C. S. Symp. Ser., 209, 191 (1983).
H. Pezzano and F. Podo,Chem. Rev., 80, 365 (1980).
K. B. Yatsimirskii, E. P. Sidorik, I. I. Volchenskova, N. N. Maidanevich, L. I. Budarin, L. M. Korchevaya, O. A. Sidorik and A. P. Burlaka,Dokl. Akad. Nauk. SSSR, 273, 632 (1983).
M. G. Basallote, R. Vilaplana and F. González Vílchez, submitted for publication.
E. N. Duesler, R. E. Tapscott, M. García-Basallote and F. Gonzaleź-Vílchez,Acta Crystallogr., C41, 678 (1985).
L. G. Purnell and D. J. Hodgson,J. Am. Chem. Soc., 98, 4759 (1976).
D. J. Hodgson,Progr. Inorg. Chem., 23, 211 (1977).
J. Arpalahti and H. Lönneberg,Inorg. Chim. Acta, 78, 63 (1983).
T. Teophanides, P. K. Ganduli and M. J. Bertrand,Anticancer Res., 1, 383 (1981).
S. Mansy, B. Rosenberg and A. J. Thomson,J. Am. Chem. Soc., 95, 1633 (1973).
J. A. Carrabine and M. Sundaraligam,J. Am. Chem. Soc., 92, 369 (1970).
C. M. Mikulsi, L. Mattucci, Y. Smith, T. B. Tran and N. M. Karyannis,Inorg. Chim. Acta, 66, L71 (1982).
B. Jezowska-Trzebiatowska, A. Antonov, H. Kozlowski and T. Cukierda,Bull. Acad. Pol. Sci., Ser. Sci., Chim., 22, 1087 (1974).
G. Pneumatikakis,Inorg. Chim. Acta, 66, 131 (1982).
J. Fujita, K. Nakamoto and M. Kobayashi,J. Am. Chem. Soc., 78, 3963 (1956).
G. Sartori, C. Furlani and A. Damiani,J. Inorg. Nucl. Chem., 8, 119 (1958).
D. M. Adams and P. J. Chandler,J. Chem. Soc., Chem. Comm., 69 (1966).
M. J. Grogan and K. Nakamoto,J. Am. Chem. Soc. 90, 918 (1968).
L. G. Marzilli, B. de Castro and C. Solorzano,J. Am. Chem. Soc., 104, 461 (1982).
D. W. Abbott and C. Woods,Inorg. Chem., 22, 597 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Basallote, M.G., Vilaplana, R. & González-Vílchez, F. Palladium and platinum guanine complexes. Transition Met Chem 11, 232–235 (1986). https://doi.org/10.1007/BF00619477
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00619477