Summary
Plasma phenytoin levels were measured in 60 patients under steady-state conditions for a period of six weeks. During the trial, the preparation of phenytoin was changed from Phenytoin BP (Regent) to Epanutin Infatabs. A significant increase in plasma phenytoin levels following the change of tablet was matched by a decrease in the number of seizures.
Similar content being viewed by others
References
Dill, W.A., Kazenko, A., Wolf, L.M., Glazko, A.J.: Studies on 5,5′-diphenylhydantoin (Dilantin) in animals and man. J. Pharmacol. exp. Ther.118, 270–279 (1956)
Eadie, M.J., Tyrer, J.M. In: Anticonvulsant therapy, p. 38. Edinburgh and London: Churchill Livingstone (1974)
Bochner, F., Hooper, W.D., Tyrer, J.H., Eadie, M.J.: Factors involved in an outbreak of phenytoin intoxication. J. neurol. Sci.16, 481–487 (1972)
Arnold, K., Gerber, N., Levy, G.: Absorption and dissolution studies on sodium diphenylhydantoin capsules. Canad. J. pharm. Sci.5, 89–92 (1970)
Lund, L.: Clinical significance of generic inequivalence of three different pharmaceutical preparations of phenytoin. Europ. J. clin. Pharmacol.7, 119–124 (1974)
Crooks, J., Weir, R.D., Coull, D.C., McNab, J.W., Calder, G., Barnett, J.W., Caie, M.B.: Evaluation of a method of prescribing drugs in hospital and a new method of recording their administration. Lancet1967 I, 668–671
Ballinger, B.R., Simpson, E., Stewart, M.J.: An evaluation of a drug administration service in a psychiatric hospital. Brit. J. Psychiat.125, 202–207 (1974)
Woodbury, D.M.: Role of pharmacological factors in the evaluation of anticonvulsant drugs. Epilepsia (Bost.)10, 121–144 (1969)
Dresner, A.J., Zarin, S.W., Wilson, M.C.: Reports of experimental and biological studies of Epanutin Infatabs. Parke-Davis Ltd. Unpublished (1973)
Richens, A.: Drug estimation in the treatment of epilepsy. Proc. roy. Soc. Med.67, 1227–1229 (1974)
Hansen, J.M., Sierbock-Nielsen, K., Skousted, L.: Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin. Pharmacol. Ther.12, 539–543 (1971)
Edwards, V.E., Eadie, M.J.: Clonazepam — a clinical study of its effectiveness as an anticonvulsant. Proc. Aust. Assoc. Neurol.10, 61–66 (1973)
Kutt, H., Haynes, J., Verebely, K., McDowell, F.: The effect of phenobarbital on plasma diphenylhydantoin levels in man and rat liver microsomes. Neurology19, 611–616 (1969)
Stewart, M.J.: Records of Department of Clinical Chemistry, Ninewells Hospital. Unpublished.
Gardener-Thorpe, C., Parsonage, M.J., Smethurst, P.F., Toothill, C.: A comprehensive gas-chromatographic scheme for the estimation of antiepileptic drugs. Clin. chim. Acta36, 223–230 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stewart, M.J., Ballinger, B.R., Devlin, E.J. et al. Bioavailability of phenytoin. A comparison of two preparations. Eur J Clin Pharmacol 9, 209–212 (1975). https://doi.org/10.1007/BF00614019
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00614019