Summary
An aqueous solution of35S-ampicillin and polyethylene glycol (PEG 4000, unabsorbable marker) was administered orally to 6 healthy subjects with gastro-intestinal tubes. The minimal absorption of radioactive material, as shown by urinary excretion of label, differed markedly between subjects and averaged 44% (25 – 67). As the mean cumulative uptake in the proximal jejunum was 31% (24 – 45), it appeared that some of the radioactivity had been taken up in more distal parts of the gastrointestinal tract. Chromatographic fractionation of gastrointestinal aspirates indicated that more than 95% of the label usually remained attached to the parent compound. The corresponding figure for radioactive material recovered from urine was about 80–85%. A similar degree of decomposition was also found for label excreted in the urine of an additional subject who received35S-ampicillin intravenously. In this experiment the urine contained 87% of the administered radioactivity.
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Swahn, A. On the absorption and metabolism of35S-ampicillin. Eur J Clin Pharmacol 9, 117–124 (1975). https://doi.org/10.1007/BF00614007
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DOI: https://doi.org/10.1007/BF00614007