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Acute haemodynamic effects of a single intravenous dose of piretanide in congestive heart failure

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Summary

The haemodynamic effect of a single 12 mg intravenous dose of piretanide was assessed in 11 patients with congestive heart failure. It dit not cause any change in cardiac output, heart rate or systemic vascular resistance, whereas the pulmonary wedge, mean pulmonary and right atrial pressures and pulmonary blood volume fell progressively, the difference from the control values being significant 5 minutes after the injection. The temporal evolution of the ratios pulmonary wedge pressure/total blood volume, pulmonary blood volume/total blood volume, right atrial pressure/total blood volume was chiefly determined by the numerator, which in all cases showed a more rapid decrease than total blood volume. Serum electrolytes remained unchanged 1 hour after the injection of the drug, except for potassium which fell from 4.9 to 4.1 mEq/l, while urinary sodium and potassium excretion were greatly increased. This high ceiling diuretic appears to have renal and venodilator properties close to those of furosemide.

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References

  1. Swan HJC (1974) Hemodynamic effects of furosemide in heart failure in man. In: Siegenthaler W, Beckerhoff R, Vetter W (eds) Diuretics in research and clinics. Int Boehringer Mannheim Symposium. pp 155–162

  2. Schrier RW, Lehman D, Zacherle B, Earley E (1973) Effects of furosemide on free water excretion in edematous patients with hyponatremia. Kidney Int 3: 30–34

    Google Scholar 

  3. Koshy MC, Mickley D, Bourgoignie J, Blaufox MD (1977) Physiologic evaluation of a new antihypertensive agent. Prazosin HCl. Circulation 55: 533–537

    Google Scholar 

  4. Gottlieb TB, Katz FH, Chidsey CA (1972) Combined therapy with vasodilator drugs and beta adrenergic blockade in hypertension. A comparative study of minoxidil and hydralazine. Circulation 45: 571–582

    Google Scholar 

  5. Biamino G, Wessel JJ, Schüren KP, Randohr B, Nöring J, Schröder R (1974) Hämodynamische Auswirkungen von Furosemid IV als Ausdruck eines direkten venodilatatorischen Mechanismus. Z Kardiol [Suppl 1]: 51

    Google Scholar 

  6. Dikshit K, Vyden JK, Forrester JS, Chatterjee K, Prakash R, Swan HJC (1973) Renal and extra renal hemodynamic effects of furosemide in congestive heart failure after myocardial infarction. N Engl J Med 1087–1090

  7. Homeida M, Roberts CJC, Dombey SL (1979) A single dose comparison of piretanide and bumetanide in congestive cardiac failure. Br J Clin Pharmacol 8: 173–178

    Google Scholar 

  8. Gillies A, Morgan T, Myers J (1980) Comparison of piretanide and chlorothiazide in the treatment of cardiac failure. Med J Aust 1: 170–172

    Google Scholar 

  9. Sharma SD, Mehra AD, Vakil BJ (1980) Piretanide (Hoe 118): single dose studies in cardiac and hepatic oedema. Turner P, Padgham C (eds) World Conference on Clinical Pharmacology and Therapeutics, London (Abstr) 401

  10. Merkel W, Bormann D, Mania D, Muschawek R, Hropot M (1976) Piretanide (Hoe 118) a new high ceiling saliduretic. Eur J Med Chem 11 [5]: 399–406

    Google Scholar 

  11. Valette H, Duhazé P, Apoil E (1979) Plethysmographic study with furosemide and piretanide in healthy volunteers. Br J Clin Pharmacol 17: 219

    Google Scholar 

  12. Valette H, Hébert JL, Raffestin B, Lockhart A, Apoil E (1980) Comparison of hemodynamic effects of furosemide and piretanide in normovolemic patients. J Cardiovasc Pharmacol 2: 103–111

    Google Scholar 

  13. Seldinger SI (1953) Catheter replacement of the needle in percutaneous angiography. A new technique. Acta Radiol 39: 273–7

    Google Scholar 

  14. Breckwlter JA, Ferguson JL, Johnson RJ, Soper RT (1963) Blood volume measurements with a new instrument. Arch Surg 86: 874–882

    Google Scholar 

  15. Shacle OW, Ferguson TB, Gregg DE, Gilford SR (1954) Evaluation of a new cuvette densitometer for determining cardiac output. Circ Res 1: 200–4

    Google Scholar 

  16. Polianski J, Valette H, Mensch-Dechene J, Allouche D, Lockhart A (1977) Extrapolation par la fonction gamma des courbes de dilution. Application au calcul du volume sanguin pulmonaire dans la bronchite chronique. Bull Eur Physiopathol Res 13: 645–657

    Google Scholar 

  17. Schreiner BF, Farnham DJ, Logan DC (1978) Underestimation of true pulmonary blood volume by the pulmonary wedge injection technique in cardiac patients. Cardiovasc Res 12,1: 56–60

    Google Scholar 

  18. Strohl A (1946) Proprietes optiques des liquides. In: Strohl A (ed) Précis de physique médicale. Masson, Paris

    Google Scholar 

  19. Lawrence JR, Ansari AF, Elliot HL, Summer DJ, Brunton GF, Whiting B, Witesmith R (1978) Kinetic and dynamic comparison of piretanide and furosemide. Clin Pharmacol Ther 23[5]: 558–565

    Google Scholar 

  20. Ogilvie RI, Ruedy J (1971) Haemodynamic effects of ethacrynic acid in anephric dogs. J Pharmacol Exp Ther 176: 389–93

    Google Scholar 

  21. Austin SM, Schreiner B, Kramer DH, Shah PM, YuPn (1976) The acute hemodynamic effects of ethacrinic acid and furosemide in patients with chronic postcapillary pulmonary hypertension. Circulation 53: 364–369

    Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Physiologie et d'Explorations cardio-pulmonaires, Université Paris-Sud, Hôpital de Bicêtre, Kremlin-Bicêtre, France

    H. Valette, J. L. Hébert & E. Apoil

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  1. H. Valette
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  2. J. L. Hébert
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  3. E. Apoil
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Valette, H., Hébert, J.L. & Apoil, E. Acute haemodynamic effects of a single intravenous dose of piretanide in congestive heart failure. Eur J Clin Pharmacol 24, 163–167 (1983). https://doi.org/10.1007/BF00613811

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  • DOI: https://doi.org/10.1007/BF00613811

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