Summary
The hypertensive effect of urapidil, a new antihypertensive agent that acts via central and peripheral alpha-adrenoceptors, has been compared with that of metoprolol in 40 patients with mild essential hypertension. Blood pressure was significantly reduced by both drugs, while the heart rate was reduced only after metoprolol. The increases in systolic blood pressure and heart rate caused by three progressive work loads of bicycle exercise were not affected during urapidil, whereas both were reduced by metoprolol. A slight reduction in forced expiratory volume was observed in some patients during treatment with the beta-blocker. There was no case of orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare and negligible with both drugs.
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References
Klemm K, Prusse W, Krüger U (1972) Synthese und physikalischemische Eigenschaften des Antihypertensivums Urapidil. Arzneimittelforsch/Drug Res 27: 1859–1897
Schoetensack W, Bischler P, Dittmann EC, Steinijans W (1977) Tierexperimentelle Untersuchungen über den Einfluß des Antihypertensivums Urapidil auf den Kruslang und die Kreislaufregulation. Arzneimittelforsch/Drug Res 27: 1908–1919
Eltze M (1979) Investigations of the mode of action of a new antihypertensive drug, Urapidil, in the isolated rat vas deferens. Eur J Pharmacol 59: 1–9
Kobrin I, Gallo AJ, Pegram BL, Frolich ED (1984) Urapidil in normotensive and spontaneously hypertensive rats: The effects on systemic and regional haemodynamics and cardiac mass. J Hypertens 2: 317–320
Schoetensack W, Bruckschen EG, Zech K (1983) Urapidil. In: Scriabine A (ed) New drug annual: Cardiovascular drugs. Raven Press, New York, pp 19–48
Haerlin R, Bruckshen EG, Henze F (1981) Antihypertensive Therapie mit Ebrantil Retardkapseln. Ergebnisse einer Multicenterstudie. Therapiewoche 31: 7930–7939
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Leonetti, G., Mazzola, C., Boni, S. et al. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension. Eur J Clin Pharmacol 30, 637–640 (1986). https://doi.org/10.1007/BF00608208
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DOI: https://doi.org/10.1007/BF00608208