Summary
Clinically relevant events possibly attributable to drug exposure have been monitored prospectively over a period of six months in 27 general intensive care units. Fifty-four events attributed to drugs were reported in 51 patients during their stay in hospital, corresponding to an overall incidence of 1.35%. The behaviour of the physicians following attribution of the events to a prescribed drug is analyzed and discussed in detail with respect to its relationship to the quality and severity of the reaction, and the classes of drugs. Twenty-four of the 4537 monitored admissions during the six months were due to life-threatening emergencies linked to the administration of drugs (14) and radio-contrast media (10) (overall incidence 0.5%). While the clinical burden attributable to adverse drug reactions in Intensive Care Units appears to be relatively small, the analysis shows that there is ample room for a greater reduction in their incidence.
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Jick H (1977) In-patient hospital surveillance for acute effects. In: Colombo F, Shapiro S, Slone D, Tognoni G (eds) Epidemiological evaluation of drugs. Elsevier, Amsterdam, pp 47–53
Auzépy PH, Durocher A, Gay R, Haegy JM, Harari A, Motin A, Poisot D, Romailho A, Tremoliéres F (1979) Accidents médicamenteux graves chez l'adulte: Incidence actuelle dans le recrutement des unités de reanimation. Nouv Presse Med 8: 1315–1318
Trunet P, Le Gall J-R, Lhoste F, Regnier B, Saillard Y, Carlet J, Rapin M (1980) The role of iatrogenic disease in admission to intensive care. J Am Med Assoc 244: 2617–2620
Brismar B, Franksson C, Sundelin P (1980) Respiratory distress syndrome. A result of disseminated intravascular coagulation (DIC) or of fluid overload. Acta Chir Scand 146: 145–148
Abramson NS, Wald KS, Grenvik AN, Robinson D, Snyder JV (1980) Adverse occurrences in intensive care units. J Am Med Assoc 244: 1582–1584
National Institutes of Health (1983) Consensus development. Crit Care Med 4, number 6
Lassen HCA, Henriksen E, Neukirch F, Kristensen HS (1956) Treatment of tetanus. Severe bone-marrow depression after prolonged nitrous-oxide anaesthesia. Lancet 1: 527–530
Amos RJ, Amess JAL, Hinds CJ, Mollin DL (1982) Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care. Lancet 2: 835–838
Ledingham IMcA, Watt I (1983) Influence of sedation on mortality in critically ill multiple trauma patients. Lancet 1: 1270
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Coordinators: Drs M. L. Farina and G. Tognoni, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan; Dr F. Procaccio, Neurosurgical ICU, Ospedale “Ca' Granda”, Niguarda, Milan.Investigators: Drs G. Barusco, Rovigo; F. Bassi, Milan; L. Bianchetti, Torino; E. Carchietti, Udine; G. Chilloni, Reggio Emilia; G. Costantini, Savigliano (CN); P. Ferrero, Aosta; E. Geat, Trento; F. Gorgerino, Torino; A. Lusini, Empoli (FI); G. Mantovani, Ferrara; S. Marchi, Bologna; P. Marcovigi, Forli; G. Marraro, Merate (CO); F. Merlo, Vicenza; E. Pagni, Bagno a Ripoli (FI); R. Pellegrino, Cuneo; C. Peruselli, Milan; A. Piovesano, Pordenone; R. Rinaldo, Cremona; R. Ruggerini, Piacenza; S. Sammartino, Torino; A. Sartore, Cittadella (PD); A. Scaglioli, Carpi (MO); G. Scopa, Terni; G. Zeffiro, Treviso; P. Zuccoli, Parma
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Italian Group on Intensive Care Evaluation (IGICE)., Farina, M.L. Epidemiology of adverse drug reactions in intensive care units. A multicentre prospective survey. Eur J Clin Pharmacol 31, 507–512 (1987). https://doi.org/10.1007/BF00606621
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DOI: https://doi.org/10.1007/BF00606621