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Parametric imaging of the rate constant Ki using [18Fluoro]-l-dopa positron emission tomography in progressive supranuclear palsy

  • Diagnostic Neuroradiology
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Abstract

Positron emission tomography (PET) studies using [18F]-l-dopa were carried out in 9 patients with supranuclear palsy and 13 controls. For quantification of PET data a rate constant Ki was calculated for the radiotracer using a graphical method. Corrections for nonspecific activity were performed in both arterial plasma and brain tissue. The purpose of this study was to test the hypothesis that parametric images of the rate constant K mapping can be obtained on a pixel-by-pixel basis using an appropriate mathematical algorithm. Ki values from these parametric images and the graphical approach were compared. Both correlated closely, with y=0.013+0.947*x, r=0.992 and y=−0.052+1.048*x, r=0.965 in patients and controls, respectively. Contrast measurements were also performed and showed a striking increase in contrast on parametric images. K mapping offers several advantages over the graphical approach, since parametric images are time-independent, i. e. one image represents the quantitative result of the study. In addition, parametric images of the rate constant are normalized to arterial plasma radioactivity and corrected for tissue metabolites. Thus, parametric images of Ki in different individuals can be compared directly without further processing in order to assess the nigrostriatal integrity.

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References

  1. Martin WRW, Palmer MR, Patlak CS, Calne DB (1989) Nigrostriatal function in humans with positron emission tomography. Ann Neurol 26: 535–542

    Google Scholar 

  2. Garnett ES, Firnau G, Nahmias C, Sood, S, Belbeck L (1980) Blood-brain barrier transport and cerebral utilization of dopa in living monkeys. Am J Physiol 238: 318–327

    Google Scholar 

  3. Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3: 1–7

    Google Scholar 

  4. Patlak CS, Blasberg RG (1985) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data: generalizations. J Cereb Blood Flow Metab 5: 584–590

    Google Scholar 

  5. Bloomfield PM, Sawle GV, Frackowiak RSJ (1991) A method for inter-subject comparison of [18F]-6-l-fluordopa positron emission tomography studies. J Cereb Blood Flow Metab 11: S 609

    Google Scholar 

  6. Ruth TJ (1985) The production of 18F-F2 and 150-02 sequentially from the same target chamber. Int J Appl Radiat Isot 36: 107–110

    Google Scholar 

  7. Adam MJ, Jivan S (1988) Synthesis and purification of L-6-[18F]fluorodopa. Appl Radiat Appl Instrum 39: 1203–1206

    Google Scholar 

  8. Evans B, Harrop R, Heywood D, Mackintosh J, Moore, RW, Pate BD, Rogers JG, Ruth TJ, Sayre C, Sprenger H, Van Oers N, Yao XG (1983) Engineering developments on the UBc-TRIUMF modified PETT VI positron emission tomograph. IEEE Trans Nucl Sci NS 30: 707–710

    Google Scholar 

  9. Chan GLY, Hewitt KA, Pate BD, Schofield P, Adam MJ, Ruth TJ (1992) Routine determination of [18F]-l-dopa and its metabolites in blood plasma is essential for accurate PET studies. Life Sci 50: 309–318

    Google Scholar 

  10. Firnau G, Garnett ES, Sourkes TL, Missala K (1975) [18F]-fluorodopa: a unique gamma emitting substrate for dopa decarboxylase. Experementia 31: 1254–1255

    Google Scholar 

  11. Guttman M, Calne DB (1988) In vivo characterization of cerebral dopamine systems in human parkinsonism. In: Jankovic J, Tolosa E (eds) Parkinson's disease and movement disorders. Urban and Schwarzenberg, Baltimore, Munich, 1988, pp 49–58

    Google Scholar 

  12. Garnett ES, Firnau G, Nahmias C (1983) Dopamine visualized in the basal ganglia of living man. Nature 305: 137–138

    Google Scholar 

  13. Martin WRW, Boyes BE, Leenders KL, Patlak CS (1985) Method for quantitative analysis of 6-fluoro-dopa uptake data from positron emission tomography. J Cereb Blood Flow Metab 5 [Suppl 1] S 593–594

    Google Scholar 

  14. Bhatt MH, Snow BJ, Martin WRW, Peppard R, Calne DB (1990) Positron emission tomography in supranuclear palsy. Arch Neurol 28: 101–103

    Google Scholar 

  15. Brooks DJ, Ibanez V, Sawle GV, Quinn N, Lees AJ, Mathias CJ, Bannister R, Marsden CD, Frackowiak RSJ (1990) Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. Ann Neurol 28: 547–555

    Google Scholar 

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Authors and Affiliations

  1. Neurodegenerative Disorders Centre, University Hospital, University of British Columbia, Vancouver, Canada

    M. Cordes, B. J. Snow & D. B. Calne

  2. Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf-Virchow, Freie Universität Berlin, Augustenburger Platz 1, D-13353, Berlin, Germany

    M. Cordes

  3. TRIUMF, University of British Columbia, Vancouver, Canada

    S. Morrison, V. Sossi & T. J. Ruth

Authors
  1. M. Cordes
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  2. B. J. Snow
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  3. S. Morrison
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  4. V. Sossi
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  5. T. J. Ruth
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  6. D. B. Calne
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Cordes, M., Snow, B.J., Morrison, S. et al. Parametric imaging of the rate constant Ki using [18Fluoro]-l-dopa positron emission tomography in progressive supranuclear palsy. Neuroradiology 35, 404–409 (1993). https://doi.org/10.1007/BF00602816

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  • DOI: https://doi.org/10.1007/BF00602816

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