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In Vivo Positron Emission Tomography of Extrastriatal Non-Dopaminergic Pathology in Parkinson Disease

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The Neuroimaging of Brain Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by the presence of both motor and non-motor symptoms. The hallmark neuropathology of PD is nigrostriatal dopaminergic denervation. Neuropathological studies, however, have also shown the involvement of extrastriatal non-dopaminergic neurotransmitter systems and Alzheimer disease (AD)-type pathology in the etiology of PD symptoms. With the advancement of new positron emission tomography (PET) radiotracers, both dopaminergic and non-dopaminergic neurotransmission systems as well as comorbid presence of AD-type proteinopathies can now be more readily assessed in vivo. We will review in vivo PET studies reporting on extrastriatal non-dopaminergic pathology in PD. We conclude that extrastriatal non-dopaminergic pathology, at least in part, may explain the heterogeneity of motor and non-motor disease manifestations in PD.

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Acknowledgments

Studies by our group reported in this chapter (Bohnen, Müller, Albin, Frey, and colleagues) were in part supported by NIH grants NS015655, NS099535, NS091856, and NS070856.

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Authors and Affiliations

  1. Department of Radiology, University of Michigan, Ann Arbor, MI, USA

    Martijn L. T. M. Müller & Nicolaas I. Bohnen

  2. Department of Neurology, University of Michigan, Ann Arbor, MI, USA

    Nicolaas I. Bohnen

  3. Morris K. Udall Center of Excellence for Parkinson’s Disease Research, University of Michigan, Ann Arbor, MI, USA

    Martijn L. T. M. Müller & Nicolaas I. Bohnen

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  1. Martijn L. T. M. Müller
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Correspondence to Martijn L. T. M. Müller .

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  1. Service de NeuroImagerie CHNO des 15/20, Paris, France

    Christophe Habas

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Müller, M.L.T.M., Bohnen, N.I. (2018). In Vivo Positron Emission Tomography of Extrastriatal Non-Dopaminergic Pathology in Parkinson Disease. In: Habas, C. (eds) The Neuroimaging of Brain Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-78926-2_7

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