Abstract
The quality of three different labeling methods of visualizing the cardiac blood pool was investigated in 72 patients:99mtechnetium labeling of red blood cells in vivo or in vitro and human serum albumin. By the simplified technique of in vitro labeling of RBC from the view point of (1) labeling efficiency, (2) activity in the blood, (3) count rates in a standard ROI over the left ventricle and the paracardiac background, (4) ratio of these count rates, and (5) evaluation of image quality, the best results were obtained. HSA and in vivo labeled RBC led to satisfactory results for visual assessment of ventricular performance in most cases. In spite of the slightly higher technical investment involved in the in vitro labeling method this technique appears to be preferable for gated cardiac blood pool studies in view of the excellent labeling quality.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Atkins HL, Klopper JF, Ansari AN, Meinken G, Richards P, Srivastava SC (1980) A comparison of Tc-99m-labeled human serum albumin and in vitro labeled red blood cells for blood pool studies. Clin Nucl Med 5:166–169
Bauer R, Bauer U, Sauer E, Langhammer H, Pabst HW (1981) In vivo/in vitro-Markierung von Erythrozyten mit99mTc und ihre klinische Anwendung. Nuc Compact 12:18–25
Buseman Sokole E, Vyth A, Raam CFM, van der Wieken LR, van der Schoot JB (1981) Improved image quality in cardiac blood pool scintigraphy with semi-in vitro labeled red blood cells. J Nucl Med 22:P-10 (Abstr)
Callahan RJ, Froelich JW, McKusick KA, Leppo J, Strauss HW (1982) A modified method for the in vivo labeling of red blood cells with99mTc: concise communication. J Nucl Med 23:315–318
Colombetti LG, Siddiqui A (1976) Efficiency of in vivo labeling of red blood cells with99mTc. Nuklearmedizin 15:211–213
Eckelman W, Richards P, Hauser W, Atkins H (1971) Technetium-labeled red blood cells. J Nucl Med 12:22–24
Fueger GF, Popescu HI (1981) Technetium reagents for cardiac function studies. Prog Radiopharmac 2:85–99
Hamilton RG, Alderson PO (1977) A comparative evaluation of techniques for rapid and efficient in vivo labeling of red cells with (99mTc) pertechnetate. J Nucl Med 18:1008–1011
Hegge FN, Hamilton GW, Larson SM, Ritchie JL, Richards P (1978) Cardiac chamber imaging: A comparison of red blood cells labeled with99mTc in vitro and in vivo. J Nucl Med 19:129–134
Holman BL (1979) Cardiac nuclear medicine: an overview. In: Cardiac nuclear medicine, Springer, Berlin Heidelberg New York, pp 1–8
Jones AG, Davis MA, Uren RF, Maddox DE (1978) Comparison of four stannous compounds for in vivo red cell labeling with99mTc. In: Nuklearmedizin, Stand und Zukunft. Schmidt HAE, Woldring M (eds). Stuttgart, New York: Schattauer, pp 171–174
Pavel DG, Zimmer AM, Patterson VN (1977) In vivo labeling of red blood cells with99mTc: a new approach to blood pool visualization. J Nucl Med 18:305–308
Schwartz KD, Krüger M (1971) Improvement in labeling erythrocytes with99mTc-pertechnetate. J Nucl Med 12:323–324
Thrall JH, Freitas JE, Swanson D, Rogers WL, Clare JM, Brown ML, Pitt B (1978) Clinical comparison of cardiac blood pool visualization with technetium-99m red blood cells labeled in vivo and with technetium-99m human serum albumin. J Nucl Med 19:796–803
Zimmer AM, Pavel DG, Karesh SM (1979) Technical parameters of in vivo red blood cell labeling with99mtechnetium. Nuklearmedizin 18:241–245
Author information
Authors and Affiliations
Additional information
Supported by SFB 89, Cardiology, Goettingen
Rights and permissions
About this article
Cite this article
Neumann, P., Schicha, H., Schürnbrand, P. et al. Visualizing cardiac blood pool: Comparison of three labeling methods. Eur J Nucl Med 8, 463–466 (1983). https://doi.org/10.1007/BF00598901
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00598901