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An investigation of the stability of the phosphate ester bond in D-pantothenic acid 4′-phosphate

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Abstract

The hydrolysis of the phosphate ester bond in D-pantothenic acid 4′-phosphate in strongly acid (9 and 6 N HCl), weakly acid, weakly alkaline, and strongly alkaline (5 N KOH) aqueous media has been studied. In strongly acid and strongly alkaline media the phosphate ester bond of (I) breaks down completely in 3 and 2.5 h, respectively. The rate of hydrolysis at pH values between 1.3 and 11 remains constantly low but almost doubles in the presence of lanthanum salts at pH 8–9 and in the presence of lithium salts at pH 4 and a molar ratio of (I):Me+=1:1.

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Authors
  1. A. G. Moiseenok
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  2. V. S. Slyshenkov
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  3. T. V. Dedovich
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Additional information

Institute of Biochemistry Academy of Sciences of the Belorussian SSR, Grodno. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 262–265, March–April, 1987.

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Moiseenok, A.G., Slyshenkov, V.S. & Dedovich, T.V. An investigation of the stability of the phosphate ester bond in D-pantothenic acid 4′-phosphate. Chem Nat Compd 23, 220–223 (1987). https://doi.org/10.1007/BF00598763

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  • DOI: https://doi.org/10.1007/BF00598763

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