Abstract
The methyl esters of colchicidylglycyl-L-leucine, -L-phenylalanine, and-L-tryptophan and the ethyl esters of colchicidylglycylglycine, -L-isoleucine,-L-valine, -L-tyrosine, and -L-glutamic acid have been obtained by the condensation of colchicidylglycine and esters of amino acids. The structures of the compounds have been confirmed on the basis of their UV spectra and nuclear magnetic resonance spectra.
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Literature cited
H. G. Capraro and A. Brossi, in: The Alkaloids, Academic Press, New York, Vol. 23 (ed. A. Brossi) (1984), p. 1.
M. K. Yusupov and A. S. Sadykov, Khim. Prir. Soedin., 3 (1978).
M. Rosner, H. G. Capraro, A. E. Jacobson, L. Atwell, and A. Brossi, J. Med. Chem.,24, 257 (1981).
P. Kereks, P. N. Sharma, A. Brossi, C. F. Cignell, and F. R. Quinn, J. Med. Chem.,28, 1204 (1985).
V. V. Kiselev, Khim. Prir. Soedin., 3 (1977).
V. V. Kiselev and N. L. Serova, Zh. Obshch. Khim.,36, No. 33 (1966).
V. V. Kiselev, Zh. Obsch. Khim.,31, 334 (1961).
V. V. Kiselev, Zh. Obshch. Khim.,34, 68 (1964).
V. V. Kiselev, Zh. Obshch. Khim.,41, 464 (1971).
S. P. Kandukuri, R. Bhushana, M.-P. M. Collard, J. P. C. Dejunghe, G. Atassi, J. A. Hannart, and A. Trouet, J. Med. Chem.,28, 1079 (1985).
A. K. Larsen, J. Paoletti, J. Beledhradek, and J. Paoletti, Jr., Cancer Res.,46, 5236 (1986).
J. P. Greenstein and M. Winits, Chemistry of the Amino Acids, Wiley, New York (1961).
The Merck Index, Merck, Rahway, N.J., eighth edition (1968), p. 278.
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Institute of Molecular Biology and Biochemistry, Kazakh SSR Academy of Sciences, Alma-Ata. Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 91–95, January–February, 1989.
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Esbolaev, E.O., Aitkhozhina, N.A. & Aleksandrova, L.A. C-10 dipertide derivatives of colchicine. Chem Nat Compd 25, 80–83 (1989). https://doi.org/10.1007/BF00596708
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DOI: https://doi.org/10.1007/BF00596708