Summary
Micropuncture investigations on the rat kidney were performed to evaluate the effect of angiotensin on tubular phosphate reabsorption.
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1.
Angiotensin increases the inorganic phosphate concentration in the blood. This increase ist dependent on the dosis of angiotensin: 0.06 μg/h·100 g enhanced inorganic plasma phosphate from 2.76±0.34 mMol/l to 3.60±0.49 mMol/l after 120 min; 6.0 μg/h·100 g enhanced to 4.48±0.98 mMol/l after 100 min.
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2.
Angiotensin increases the tubular phosphate load and the phosphate excretion.
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3.
The fractional phosphate reabsorption was not influenced by angiotensin.
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4.
No relationship was found between the effect of angiotensin on the plasma phosphate level and the phosphate excretion in relation to the changes in glomerular filtration rate.
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5.
This results indicate that angiotensin has no direct effect upon tubular phosphate reabsorption.
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6.
The possible metabolic effect of angiotensin due to plasma phosphate is considered.
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Gekle, D., von Carlowitz, B. & Geisel, U. Micropuncture investigations on the effect of angiotensin on the inorganic phosphate reabsorption in the proximal tubule of the rat. Pflugers Arch. 342, 73–82 (1973). https://doi.org/10.1007/BF00593251
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DOI: https://doi.org/10.1007/BF00593251