Summary
Somato-vegetative reflexes elicited by electrical stimulation of various spinal afferents and the effect of conditioning were investigated in immobilized cats, conscious or anaesthetized with chloralose or urethane. Test stimuli (1–2–4 imp/s) were applied before and after higher frequency (30 imp/s) conditioning stimulation on the same (homotopic conditioning) or different (heterotopic conditioning) nerves. Changes in reflex blood pressure responses and in renal sympathetic efferent activity were evaluated.
In case of homotopic conditioning facilitation of reflexes was observed in anaesthetized cats. It manifested itself in reversal of depressor reactions into biphasic or pressor ones and in the appearance of marked reflex discharges in the sympathetic efferent activity, if the testing stimulations involved A-fibre afferents only. Pressor reflexes elicited by testing stimulations of A+C-afferents were enhanced; in the renal neurograms second bursts of discharges (C-reflexes) appeared or, if they had been present, were enlarged.
Facilitation failed 1. if conditioning stimulation was not strong enough to excite C-fibre afferents; 2. in case of heterotopic stimulations; 3. in conscious animals independently of the site of conditioning. Depression of reflexes could be observed if heterotopic conditioning was performed in urethane anaesthesia or in conscious animals.
It is concluded that post-tetanic facilitation of sympathetic reflexes may be due to enhanced excitability of the first spinal interneurons; controlling role of supraspinal influences is admitted.
Similar content being viewed by others
References
Balis, G. U., Monroe, R. R.: The pharmacology of chloralose. Psychopharmacologia (Berl.)6, 1–30 (1964).
Brown, G. L., Holmes, O.: The effects of activity on mammalian nerve fibres of low conduction velocity. Proc. roy. Soc. B145, 1–14 (1956).
Cragg, B. G.: Effect of disuse upon a reflex with an unmyelinated afferent limb. Exp. Neurol.12, 190–197 (1965).
Eccles, J. C., McIntyre, A. R.: The effects of disuse and of activity on mammalian spinal reflexes. J. Physiol. (Lond.)121, 492–516 (1953).
Fedina, L., Katunskii, A. Ya., Khayutin, V. M., Mitsányi, A.: Responses of renal sympathetic nerves to stimulation of afferent A and C fibres of tibial and mesenterial nerves. Acta physiol. Acad. Sci. hung.29, 157–176 (1966).
Khayutin, V. M.: Vasomotor reflexes. Moscow: Nauka 1964 (in Russian).
Khayutin, V. M.: Specific and non-specific responses of the vasomotor centre to impulses of spinal afferent fibres. Acta physiol. Acad. Sci. hung.29, 131–144 (1966).
Khayutin, V. M., Lukoshkova, E. V.: Spinal mediation of vasomotor reflexes in animals with intact brain studied by electrophysiological methods. Pflügers Arch.321, 197–222 (1970).
Khayutin, V. M., Mitsányi, A.: Post-tetanic facilitation in transmission of impulses of sciatic nerve C-afferents to vasomotor neurons. Bull. exp. Biol. Med. (in press) (1972) (in Russian).
Kumazawa, T., Naotsuka, T.: Inhibition of galvanic skin response by the splanchnic afferent. Experientia (Basel)26, 148–149 (1970).
Laporte, Y., Bessou, P., Bouisset, S.: Action réflexe des différents types de fibres afférentes d'origine musculaire sur la pression sanguine. Arch. ital. Biol.98, 206–221 (1960).
Laporte, Y., Montastruc, P.: Rôle des différentes types de fibres afférentes dans les réflexes circulatoires généraux d'origine cutanée. J. Physiol. (Paris)49, 1039–1049 (1957).
Mendell, L. M.: Physiological properties of unmyelinated fiber projection to the spinal cord. Exp. Neurol.16, 316–332 (1966).
Mendell, L. M., Wall, P. D.: Responses of single dorsal cord cells to peripherial cutaneous unmyelinated fibres. Nature (Lond.)206, 79–99 (1965).
Pavlik, G., Morava, I., Mitsányi, A., Erdélyi, A.: Dependence of circulatory reflexes elicited by electrical stimulation of spinal afferents on the depth of anaesthesia caused by various anaesthetics. Acta physiol. Acad. Sci. hung.39, 241–242 (1971).
Schmidt, R. F., Weller, E.: Reflex activity in the cervical and lumbar sympathetic trunk induced by unmyelinated somatic afferents. Brain Res.24, 207–218 (1970).
Sell, R., Erdélyi, A., Schaefer, H.: Untersuchungen über den Einfluß peripherer Nervenreizung auf die sympatische Aktivität. Pflügers Arch. ges. Physiol.267, 566–581 (1958).
Sonina, R. S.: Vasomotor reflexes from small intestine receptive zone after acute brain anemization. Physiol. Zh. (Mosk.)54, 568–576 (1968) (in Russian).
Sonina, R. S.: Summation properties of the spinal vasomotor reflex arc. Bull. exp. Biol. Med.67/5, 7–9 (1969a) (in Russian).
Sonina, R. S.: Effect of pontine structures on vasomotor reflexes in response to mesenterial and sciatic nerve impulses. Trudy Inst. norm. pathol. Physiol. AMN SSSR12, 22–24 (1969b) (in Russian).
Sonina, R. S., Khayutin, V. M.: Temporal dispersion in afferent pathways and in realization of vasomotor reflexes in spinal preparations. Dokl. Acad. Nauk SSSR198, 483–485 (1971) (in Russian).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lukoshkova, E.V., Pavlik, G. Post-tetanic facilitation of vasomotor reflexes elicited by electrical stimulation of spinal afferents. Pflugers Arch. 336, 134–146 (1972). https://doi.org/10.1007/BF00592928
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00592928