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Chromosome assignments of the genes for glucocorticoid receptor, myelin basic protein, leukocyte common antigen, and TRPM2 in the rat

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Abstract

We have utilized rat-mouse somatic cell hybrids to make chromosomal assignments for the glucocorticoid receptor (GR), myelin basic protein (MBP), leukocyte common antigen (LCA), and testosterone-repressed prostate message-2 (TRPM2) genes in the rat. The genes for GR and MBP both map on chromosome 18 of the rat, which corresponds to the mapping of both genes on chromosome 18 of the mouse. The gene for LCA maps on chromosome 13, which is where C4b-binding protein β-chain (C4BPB), coagulation factor V (F5), and renin have previously been assigned. This linkage group appears to be homologous to a substantial portion of mouse chromosome 1 and human chromosome 1q. Finally, the TRPM2 gene has been assigned to rat chromosome 15.

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Authors and Affiliations

  1. Department of Human Genetics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, 19104, Philadelphia, Pennsylvania

    Audrey Goldner-Sauvé & David L. Gasser

  2. Department de Biologie Moleculaire, Universite Libre de Bruxelles, Rue des Cheveaux 67, B-1640, Rhode-St-Genese, Belgium

    Claude Szpirer & Josiane Szpirer

  3. Department of Genetics, University of Gothenburg, Box 33031, S-40033, Gothenburg, Sweden

    Goran Levan

Authors
  1. Audrey Goldner-Sauvé
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  2. Claude Szpirer
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  3. Josiane Szpirer
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  4. Goran Levan
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  5. David L. Gasser
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Additional information

This project was supported by Grants RG 1877-A-1 from the National Multiple Sclerosis Society and P50 DE09164 from the NIH, by grants from the Swedish Cancer Society, the Erik Philip-Sörensen Foundation, the Trygger Foundation, the IngaBritt and Arne Lundberg Research Foundation, CANCIRCO, and BioVast (Gothenbrug), by the Belgian program on Interuniversity Attraction Poles initiated by the Belgian State-Prime Minister's Office-Science Policy Programming, and by a grant from the CGER-ASLK (Brussels). C.S. is a Senior Research Associate of the National Fund for Scientific Research (FNRS, Belgium).

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Goldner-Sauvé, A., Szpirer, C., Szpirer, J. et al. Chromosome assignments of the genes for glucocorticoid receptor, myelin basic protein, leukocyte common antigen, and TRPM2 in the rat. Biochem Genet 29, 275–286 (1991). https://doi.org/10.1007/BF00590108

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  • DOI: https://doi.org/10.1007/BF00590108

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