Skip to main content

Advertisement

SpringerLink
Log in

Database for serial magnetic resonance imaging in multiple sclerosis

  • Diagnostic Neuroradiology (Brain)
  • Published:
Neuroradiology Aims and scope Submit manuscript

Abstract

The unique sensitivity of magnetic resonance imaging (MRI) in detecting disease activity in multiple sclerosis (MS) and the objective nature of the information obtained suggest that MRI will be a useful and reliable way of monitoring treatment trials. There is a need to develop an appropriate database which would provide a standardised means of assessment, not only of MRI, but also of essential clinical information. As part of the program of Concerted Action in Multiple Sclerosis, funded by the Commission of the European Community (CEC), we have developed a database for recording serial brain MRI results. The database consists of core, entry and follow-up sections. Both entry and follow-up parts are subdivided into clinical, MR system and MRI data. We expect that the use of this database will maximise efficiency of MRI monitoring in MS treatment trials, particularly in multicentre studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Miller DH, Barkhof F, Berry I, Kappos L, Scotti G, Thompson AJ (1991) Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: Concerted Action guidelines. J Neurol Neurosurg Psychiatry 54:683–688

    Google Scholar 

  2. Poser CM, Paty DW, Scheinberg L, et al (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231

    Google Scholar 

  3. Thompson AJ, Kermode AG, Wicks D, et al (1991) Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol 29:53–62

    Google Scholar 

  4. Thompson AJ, Miller D, Youl B, et al (1992) Serial gadolinium enhanced MRI in relapsing remitting multiple sclerosis of varying disease duration. Neurology 42:60–63

    Google Scholar 

  5. Barkhof F, Hommes OR, Scheltens P, Valk J (1991) Quantitative MRI changes in gadolinium-DTPA enhancement after highdose intravenous methylprednisolone in multiple sclerosis. Neurology 41:1219–1222

    Google Scholar 

  6. Burham JA, Wright RR, Dreisbach J, Murray RS (1991) The effect of high-dose steroids on MRI gadolinium enhancement in acute demyelinating lesions. Neurology 41:1349–1354

    Google Scholar 

  7. Miller DH, Thompson AJ, Morrissey SP, et al (1992) High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effect. J Neurol Neurosurg Psychiatry 55 (in press)

  8. Hawkins CP, Munro PMG, MacKenzie F, et al (1990) Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied by gadolinium-DTPA and protein markers. Brain 113: 365–378

    Google Scholar 

  9. Katz D, Taubenberger J, Raine C, McFarlin D, McFarland H (1990) Gadolinium-enhancing lesions on magnetic resonance imaging: neuropathological findings. Ann Neurol 28:243

    Google Scholar 

  10. Kuharik MA, Edwards MK, Farlow MR, et al (1988) Gd-enhanced MR imaging of acute and chronic experimental dymyelinating lesions. AJNR 9:643–648

    Google Scholar 

  11. Harris JO, Frank JA, Patronas N, McFarlan DE, McFarland HF (1991) Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis:implications for clinical trials. Ann Neurol 29:548–555

    Google Scholar 

  12. Bastianello S, Pozzili C, Bernardi S, et al (1990) Serial study of gadolinium-DTPA MRI enhancement in multiple sclerosis. Neurology 40:591–595

    Google Scholar 

  13. Miller DH, Rudge P, Johnson G, et al (1988) Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. Brain 111:927–939

    Google Scholar 

  14. Grossman RI, Braffman BH, Brorson JR, Goldberg HI, Silberberg DH, González-Scarano F (1988) Multiple sclerosis: serial study of a gadolinium-enhanced MR imaging. Radiology 169: 117–122

    Google Scholar 

  15. Barkhof F, Scheltens P, Frequin STFM, Nauta JJP, Tas MW, Valk J, Hommes OR (1992) Relapsing-remitting multiple sclerosis: sequential enhanced MR imaging vs clinical findings in determining disease activity. AJR 159:1041–1047

    Google Scholar 

  16. Kermode AG, Thompson AJ, Tofts P, et al (1990) Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions multiple sclerosis. Brain 113:1477–1489

    Google Scholar 

  17. Larsson HBW, Stubgaard M, Frederiksen JL, Jensen M, Henriksen O, Paulson OB (1990) Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn Res Med 16:117–131

    Google Scholar 

  18. Paty DW (1991) Multiple sclerosis with an emphasis on MR imaging. In: Appel SH (ed) Current neurology. Mosby, St. Louis, pp 169–198

    Google Scholar 

  19. Wicks D, Tofts PS, Miller DH, et al (1992) Volume measurements of multiple sclerosis lesions with magnetic resonance imaging: a preliminary study. Neuroradiology 34:475–479

    Google Scholar 

  20. Truyen L, Gheuens J, Parizel PM, Van de Vyver FL, Martin JJ (1991) Long term follow-up of multiple sclerosis by standardized, non-contrast-enhanced magnetic resonance imaging. J Neurol Sci 106:35–40

    Google Scholar 

  21. Paty DW (1988) Trial measures in multiple sclerosis: the use of magnetic resonance imaging in the evaluation of clinical trials. Neurology 38 [Suppl 2]:82–83

    Google Scholar 

  22. Paty DW, Oger JJF, Kastrukoff LF, et al (1988) MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. Neurology 38:180–185

    Google Scholar 

  23. Uhlenbrock D, Seidel D, Gehlen W, et al (1988) MR imaging in multiple sclerosis: comparison with clinical, CSF, and visual evoked potentials. AJNR 9:59–67

    Google Scholar 

  24. Ormerod IEC, Miller DH, McDonald WI, et al (1987) The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological syndromes: a quantitative study. Brain 110: 1579–1616

    Google Scholar 

  25. Isaac C, Li DKB, Genton M, et al (1988) Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 38: 1511–1515

    Google Scholar 

  26. Willoughby EW, Grochowski E, Li DKB, et al (1989) Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients. Ann Neurol 25:43–49

    Google Scholar 

  27. Koopmans RA, Li DKB, Oger JJF, et al (1989) Chronic progressive multiple sclerosis: serial magnetic resonance brain imaging over six months. Ann Neurol 26:248–256

    Google Scholar 

  28. Kappos L, Städt D, Ratzka M, et al (1988) Magnetic resonance imaging in the evaluation of treatment in multiple sclerosis. Neuroradiology 30:299–302

    Google Scholar 

  29. Kurtzke JF (1983) Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452

    Google Scholar 

  30. Francis DA, Bain P, Swan AV, Hughes RAC (1991) An assessment of disability rating scales used in multiple sclerosis. Arch Neurol 48:299–301

    Google Scholar 

  31. Noseworthy JH, Vandervoort MK, Wong CJ, Ebers GC and the Canadian Cooperative MS Study Group (1990) Interrater variability with the Expanded Disability Status Scale (EDSS) and Functional Systems (FS) in a multiple sclerosis clinical trial. Neurology 40:971–975

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, Free University Hospital, P.O. Box 7057, NL-1007 MB, Amsterdam, The Netherlands

    F. Barkhof

  2. University Department of Clinical Neurology, Institute of Neurology, London, UK

    A. J. Thompson, P. S. Tofts & D. H. Miller

  3. University Department of Neurology, Kantonsspital Basel, Basel, Switzerland

    L. Kappos

  4. Department of Theory of Medicine, Epidemiology and Biostatistics, Free University Hospital, Amsterdam, The Netherlands

    J. J. P. Nauta

  5. Radiologische Klinik und Poliklinik, Klinikum Grosshadern, Munich, Germany

    T. Yousri

  6. Departments of Neuroradiology and Nuclear Medicine, Purpan and Rangeuil University Hospitals, Toulouse, France

    I. Berry

  7. Department of Neuroradiology, Istituto Scientifico H S Rafaelle, Milan, Italy

    G. Scotti

  8. Department of Neuroradiology, Academic Hospital Middelheim, Antwerp, Belgium

    B. Appel

Authors
  1. F. Barkhof
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. J. Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Kappos
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. J. P. Nauta
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Yousri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. Berry
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. Scotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. B. Appel
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. P. S. Tofts
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. D. H. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barkhof, F., Thompson, A.J., Kappos, L. et al. Database for serial magnetic resonance imaging in multiple sclerosis. Neuroradiology 35, 362–366 (1993). https://doi.org/10.1007/BF00588371

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00588371

Key words

Search

Navigation