Skip to main content
SpringerLink
Log in

Role of cyclic nucleotides in receptor mechanisms

  • Topic III: Drug Receptor Interaction in Brain
  • Published:
Naunyn-Schmiedeberg's Archives of Pharmacology Aims and scope Submit manuscript

Summary

A norepinephrine-sensitive cyclic AMP generating system is present in slices of rat limbic forebrain. The system has properties of a noradrenergic receptor and seems to be involved in the action of psychotropic drugs. It is hypothesized that desensitization of the system is the basis of action of psychic antidepressants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Blumberg, J.B., Taylor, R.D., Sulser, F.: Blockade by pimozide of a noradrenaline sensitive adenylate cyclase in the limbic forebrain: Possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics. J. Pharm. Pharmacol. 27, 125–128 (1975).

    Google Scholar 

  • Blumberg, J.B., Vetulani, J., Stawarz, R.J., Sulser, F.: The noradrenergic cyclic AMP generating system in the limbic forebrain: Pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics. Europ. J. Pharmacol. 37, 357–366 (1976).

    Google Scholar 

  • Vetulani, J., Stawarz, R.J., Dingell, V.D., Sulser, F.: A possible common mechanism of action of antidepressant treatments: Reduction in the sensitivity of the noradrenergic cyclic AMP generating system in the rat limbic forebrain. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 109–114 (1976a).

    Google Scholar 

  • Vetulani, J., Stawarz, R.J., Sulser, F.: Adaptive mechanisms of the noradrenergic cyclic AMP generating system in limbic forebrain of the rat: Adaptation to persistent changes in the availability of norepinephrine. J. Neurochem. (in press, 1976b).

  • Vetulani, J., Sulser, F.: Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature (Lond.) 257, 495–496 (1975).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

    Jerzy Vetulani

Authors
  1. Jerzy Vetulani
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The experimental part was done at the Tennessee Neuropsychiatric Institute and Department of Pharmacology of the Vanderbilt University Medical School in Nashville, Tennessee, U.S.A., and was supported by USPHS grant MH-11468.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vetulani, J. Role of cyclic nucleotides in receptor mechanisms. Naunyn-Schmiedeberg's Arch. Pharmacol. 297 (Suppl 1), S45–S46 (1977). https://doi.org/10.1007/BF00587773

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00587773

Keywords

Search

Navigation