Summary
The authors' modified rat open cremaster muscle preparation as a model to study vasospasm by in vivo microscopy is presented. Vasospasm of cremaster microvessels was induced using adrenaline. Spasmolytic action after topical application of various pharmacologic solutions was evaluated. Phentolamine has the strongest spasmolytic action to arterial spasm, thus, it appears that phentolamine may be the spasmolytic agent of choice. NAA, papaverine and reserpine show a degree of vasospasm reversal while magnesium sulfate and danshen compound are ineffective. Tolazoline has a biphasic action to spasmodic vessels. Lidocaine has a strong spasmodic effect on cremaster arterioles. The authors therefore propose that the local application of tolazoline or lidocaine as a spasmolytic agent in microsurgery should be revised.
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Huang, G.K., Li, H.Q. Relief of vasospasm by drugs: an experimental study. Eur J Plast Surg 14, 10–14 (1991). https://doi.org/10.1007/BF00585581
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DOI: https://doi.org/10.1007/BF00585581