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Influence of sympathectomy on human peripheral nerve regeneration after autoneuroplasty

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Abstract

86 patients with posttraumatic defects of the median and ulnar nerves were examined. Autoneuroplasty was performed in all patients: in 42 patients, in combination with sympathectomy (thoracoscopic clipping of the Th3–Th4 sympathetic trunk ganglia); in 44 patients, without sympathectomy. Ultrasonography of nerve trunks, stimulation electroneuromyography, computer thermography, and laser Doppler flowmetry with a spectral wavelet analysis of blood flow oscillations were used in the examination. It was demonstrated that sympathectomy has a positive activating effect on the recovery of innervation and tissue trophism in the process of posttraumatic regeneration of peripheral nerves. A combination of autoneuroplasty with sympathectomy promotes a more complete recovery of motor and sensory nerve fibers, normalization of blood flow in the microvascular bed, and thermal topography of the damaged limb segment, including those in the area of previously denervated tissues.

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Correspondence to A. I. Krupatkin.

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Original Russian Text © M.V. Merculov, I.O. Golubev, A.I. Krupatkin, 2015, published in Fiziologiya Cheloveka, 2015, Vol. 41, No. 2, pp. 91–97.

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Merculov, M.V., Golubev, I.O. & Krupatkin, A.I. Influence of sympathectomy on human peripheral nerve regeneration after autoneuroplasty. Hum Physiol 41, 190–195 (2015). https://doi.org/10.1134/S0362119715020139

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