Conclusions
1. With respect to the main physical, mechanical, optical, and physicochemical characteristics PMMA, polypropylene, and polyamide, and also ready-made IOL treated with gamma radiation in doses of 25, 50, and 100 kGy remain suitable for long use of these materials and IOL made from them in the eye.
2. Microbiological investigations showed the expediency of using for radiation sterilization of artificial crystalline lenses a dose of 25 kGy, for which a reliability of sterility not less than 106 is obtained.
3. The use of the “accelerated aging” method for structural materials subjected to irradiation and ready-made IOL did not cause an additional change in the main characteristics.
4. The expected minimum time during which the properties of irradiated IOL should remain constant were estimated by calculation (12–15 years). If a change in these parameters of the IOL within limits up to 10% is permissible, the time increases to 100 years.
5. Implantation of the radiation-sterilized lenses in the eyes of experimental animals did not make it possible to reveal during the post-operative period deviations in the investigated eye compared with the control (aphakic) eye.
6. The method can be recommended for testing in clinical practice.
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Additional information
Scientific-Research Institute of Ocular Microsurgery, Moscow, RSFSR. Translated from Meditsinskaya Tekhnika, No. 5, pp. 22–29, September–October, 1985.
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Ovchinnikova, A.V., Osipov, A.V., Gorbunov, Y.S. et al. Radiation sterilization of intraocular lenses. Biomed Eng 19, 141–147 (1985). https://doi.org/10.1007/BF00584925
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DOI: https://doi.org/10.1007/BF00584925