Abstract
The respiratory effects of forced changes of alveolar\(P_{CO_2 } \) were studied in four healthy human subjects and in one anaesthetized cat. Solenoid valves, triggered by changes in mouth pressure, allowed changes from one inspiratory gas mixture to another, either during expiration (between-breath changes, BBC) or in the middle of inpiration (within-breath changes, WBC). In BBC the subject breathed CO2-free gas in one inspiration, CO2-rich gas in the next, and so on; end-tidal\(P_{CO_2 } \) alternated regularly from breath to breath by 1.1 kPa. In WBC CO2-free gas was given early in one inspiration and late in the next, with CO2-rich gas late in the former and early in the latter, and so on end-tidal\(P_{CO_2 } \) was nearly constant from breath to breath. Eight respiratory output variables were analysed. WBC induced small but significant alternation in most of the variables; these effects occurred almost exclusively in runs in hypoxia. The responses were not very different from those seen in BBC. The experiment on the cat showed that the alveolar\(P_{CO_2 } \) changes predicted during WBC are reflected by changes in pH in the arterial blood. The results confirm predictions based upon observations in the steady state of tube- and reversed-tube breathing in man. It seems likely that the responses are mediated by the arterial chemoreceptors responding to small changes in the profile of the (CO2, H+) oscillation.
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Band DM, Semple SJG (1967) Continuous measurement of blood pH with an indwelling arterial glass electrode. J Appl Physiol 22:854–857
Band DM, Wolff CB (1978) Discharge frequency of chemoreceptor afferents in sinus nerve of anaesthetized cats at normal and low arterial oxygen tensions. J Physiol 282:1–6
Band DM, Cameron IR, Semple SJR (1969) Effect of different methods of CO2 administration on oscillations of arterial pH in the cat. J Appl Physiol 26:268–273
Band DM, Cameron IR, Semple SJG (1970) The effect on respiration of abrupt changes in carotid artery pH and\(P_{CO_2 } \) in the cat. J. Physiol 211:479–494
Band DM, McClelland M, Philips DL, Saunders KB, Wolff CB (1978) Sensitivity of the carotid body to within-breath changes in arterial\(P_{CO_2 } \) J Appl Physiol 45:768–777
Bartoli A, Cross BA, Guz A, Jain SK, Noble MIM, Trenchard DW (1974) The effect of carbon dioxide in the airways and alveoli on ventilation; a vagal reflex studied in the dog. J Physiol 240:91–109
Bernards JA, Sistermans JF (1969) Transient changes in lung ventilation by brief stimulation of the carotid bodies in the dog. Acta Physiol Pharmacol Neerl 15:28–29
Black AMS, Torrance RW (1971) Respiratory oscillations in chemoreceptor discharge in the control of breathing. Respir Physiol 13:221–237
Black AMS, McCloskey DI, Torrance RW (1971) The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli. Respir Physiol 13:36–49
Bradley GW, Noble MIM, Trenchard D (1976) The direct effect on pulmonary stretch receptor discharge produced by changing lung carbon dioxide concentration in dogs on cardiopulmonary bypass and its action on breathing. J Physiol 261:359–373
Coleridge HM, Coleridge JCG, Banzett RB (1978) Effect of CO2 on afferent vagal endings in the canine lung. Respir Physiol 34:135–151
Cowell TK, Band DM, Semple SJG (1967) A fast-response pH meter. J Appl Physiol 22:858–860
Cunningham DJC (1974) Integrative aspects of the regulation of breathing: a personal view. In: Widdicombe JG (ed) MTP Int Rev of Sci Respiratory Physiology. Butterworths, London, pp 303–369
Cunningham DJC, Howson MG, Pearson SB (1973) The respiratory effects in man of altering the time profile of alveolar CO2 and O2 within each respiratory cycle. J Physiol 234:1–28
Cunningham DJC, Drysdale DB, Gardner WN, Jensen JI, Petersen E Strange, Whipp BJ (1977) Very small, very short-latency changes in human breathing induced by step changes of alveolar gas composition. J Physiol 266:411–421
Cunningham DJC, Howson MG, Metias EF, Petersen E Strange (1980) Dynamic changes in the time profile of the alveolar oscillations of\(P_{CO_2 } \) and their effects on the pattern of breathing in man. Bull Physiol Path Resp 16:218–219
Delpierre S, Jammes Y, Mei N (1980) Effects of hypercapnia, hypoxia and increase in tidal volume on vagal bronchopulmonary C fibres in cat. J Physiol 298:48–49 P
DuBois AB, Britt AG, Fenn WO (1952) Alveolar CO2 during the respiratory cycle. J Appl Physiol 4:535–548
Dutton RE, Hodson WA, Davies DG, Fenner A (1967) Effect of the rate of rise of carotid body\(P_{CO_2 } \) on the time course of ventilation. Resp Physiol 3:367–379
Eldridge FL )1972) The importance of timing on the respiratory effects of intermittent carotid sinus nerve stimulation. J Physiol 222:297–318
Fenner A, Jansson EH, Avery ME (1968) Enhancement of the ventilarory response to carbon dioxide by tube breathing. Respir Physiol 4:91–100
Fitzgerald RS, Parks DC (1971) Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats. Respir Physiol 12:218–229
Gardner WN (1977) The relation between tidal volume and inspiratory and expiratory times during steady-state carbon dioxide inhalation in man. J Physiol 272:591–611
Gardner WN (1980) The pattern of breathing following step changes of alveolar partial pressures of carbon dioxide and oxygen in man. J Physiol 300:55–73
Goode RC, Brown Jr EB, Howson MG, Cunningham DJC (1969) Respiratory effects of breathing down a tube. Respir Physiol 6:343–359
Heeringa J, Berkenbosch A, de Goede J, Olievier CN (1979) Relative contribution of central and peripheral chemoreceptors to the ventilatory response to CO2 during hyperoxia. Respir Physiol 37:365–379
Lahiri S, Delaney RG (1975) Realationship between caroid chemoreceptor activity and ventilation in the cat. Respir Physiol 24:267–286
Marsh RHK, Lyen KR, McPherson GAD, Pearson SB, Cunningham DJC (1973) Breath-by-breath effects of imposed alternalte-breath oscillations of alveolar CO2. Respir Physiol 18:80–91
Metias EF (1980) The effects of within-breath alternation of the time profile of alveolar\(P_{CO_2 } \) on the termination of inspiration in man. J Physiol 301:65–66 P
Metias EF, Cunningham DJC, Howson MG, Petersen E Strange, Wolff CB (1978) The reflex effects on the human respiratory pattern of alternating the time profile of inspiratory\(P_{CO_2 } \) during steady hypoxia. Pflügers Arch 373:R39
Mustafa MEKY, Purves MJ (1972) The effect of CO2 upon discharge from slowly-adapting stretch receptors in the lungs of rabbits. Respir Physiol 16:197–212
Pearson SB, Wolf CB (1975) The effects of abnormal oxygen tensions on breath by breath tidal volume changes in cats alternately breathing CO2-rich and CO2-free gas mixtures. J Physiol 251:38–40
Priban IP (1963) An analysis of some short-term patterns of breathing in man at rest. J Physiol 166:425–434
Sokal RR, Rohlf FJ (1969) Biometry. The principles and practice of statistics in biological research. San Francisco: Freedman p 399–401
Swanson GD, Bellville JW (1975) Step changes in end-tidal CO2: methods and implications. J Appl Physiol 39:377–385
Ward SA, Cunningham DJC (1977a) The relation between hypoxia and CO2-induced reflex alternation of breathing in man. Respir Physiol 29:363–378
Ward SA, Cunningham DJC (1977b) Separation of the inspiratory and expiratory reflex effects of alternate-breath oscillation of\(P_{A,CO_2 } \) during hypoxia. Respir Physiol 29:379–390
Ward SA, Drysdale DB, Cunningham DJC, Petersen E Strange (1979) Inspiratory-expiratory responses to alternate-breath oscillation of\(P_{A,CO_2 } \) and\(P_{A,O_2 } \). Respir Physiol 36:311–325
Yamamoto WS (1960) Mathematical analysis of the time course of alveolar CO2. J Appl Physiol 15:215–219
Yokota H, Kreuzer F (1963) Alveolar to arterial transmission of oxygen fluctuations due to respiration in anaesthetized dogs. Pflügers Arch 340:291–306
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Supported by a grant awarded by the Medical Research Council. E. F. Metias was supported by an Egyptian government grant
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Metias, E.F., Cunningham, D.J.C., Howson, M.G. et al. Reflex effects on human breathing of breath-by-breath changes of the time profile of alveolar\(P_{CO_2 } \) during steady hypoxia. Pflugers Arch. 389, 243–250 (1981). https://doi.org/10.1007/BF00584785
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DOI: https://doi.org/10.1007/BF00584785