Abstract
The effects of intravenous infusions of the stable prostaglandin analogue 9-deoxo-16,16-dimethyl-9-methylene-PGE2 (9-methylene-PGE2) in a dosage of 10 or 24 μg/min were studied in the consicious euhydrated, dehydrated, and hyperhydrated with the simultaneous administration of exogenous arginine vasopressin (AVP), sheep. The infusions decreased urine osmolality and increased urine flow and renal free water clearance. The results indicate that 9-methylene-PGE2 exhibits its diuretic effect by antagonizing the antidiuretic action of AVP. In the hyperhydrated sheep receiving AVP the syndrome of inappropriate antidiuretic hormone release (SIADH) was simulated. As the prostaglandin analogue effectively blocked the antidiuretic effect of the AVP-administration it appears that 9-methylene-PGE2 may play a future role as a diuretic agent, especially in conditions characterized by water retention and dilutional hyponatremia such as SIADH.
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References
Andersson B, Leksell LG, Lishajko F (1975) Perturbations in fluid balance induced by medially placed forebrain lesions. Brain Res 99:261–275
Bartter FC, Schwartz WB (1967) The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:790–806
Bygdeman M, Bremme K, Christensen N, Lundström V, Greén K (1980) A comparison of two stable prostaglandin E analogues for termination of early pregnancy and for cervical dilatation. Contraception 22 No 5:471–483
Cooke CR, Turin MD, Walker WG (1979) The syndrome of antidiuretic hormone secretion (SIADH): Pathophysiologic mechanism in solute and volume regulation. Medicine 58:240–251
Grantham J, Orloff J (1968) Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′,5′-monophosphate and theophylline. J Clin Invest 47:1154–1161
Greén K, Kimball FA, Thornburgh BA, Wickrema-Sinha A (1980) Quantitative determination of 9-deoxo-16,16-dimethyl 19-methylene-PGE2 in human plasma by GC-MS, RIA and HPLC. Prostaglandins 20:767–780
Greén K, Vesterqvist O, Bygdeman M, Christensen NJ, Bergström S (1982) Plasma levels of 9-deoxo-16,16-dimethyle-9-methylene-PGE2 in connection with its development as an abortifacient. Prostaglandins 24 No 4:451–466
Gross JB, Bartter FC (1973) Effects of prostaglandins E1, A1 and F2alfa on renal handling of salt and water. Am J Physiol 225:218–224
Gross PA, Schrier RW, Anderson RJ (1981) Prostaglandins and water metabolism: A review with emphasis on in vivo studies. Kidney Int 19:839–850
Johnston HH, Herzog JP, Lauler DP (1967) Effect of prostaglandin E1 on renal hemodynamics, sodium and water excretion. Am J Physiol 213:939–946
Kokko JP (1981) Effects of prostaglandins on renal epithelial electrolyte transport. Kidney Int 19:791–796
Leksell LG (1978) Effects on fluid balance induced by non febrile intracerebroventricular infusion of PGE2, PGF2alfa and arachidonic acid in the goat. Acta Physiol Scand 104:225–231
Lipson LC, Sharp GWG (1971) Effect of prostaglandin E1 on sodium transport and osmotic water flow in the toad bladder. Am J Physiol 220:1046–1052
Milton AS (1982) Prostaglandins in fever and the mode of action of antipyretic drugs. In: Milton AS (ed) Handbook of Experimental Pharmacology. No 60, Pyretics and Antipyretics. pp. 257–303. Springer, Berlin Heidelberg New York
Orloff J, Handler J, Bergström S (1965) Effects of prostaglandin (PGE1) on the permeability response of toad bladder to vasopressin, theophylline and adenosine 3′,5′ monophosphate. Nature London 205:397–398
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Christensen, NJ., Bygdeman, M., Greén, K. et al. The prostaglandin-analogue-9-deoxo-16,16-dimethyl-9-methylene-PGE2 inhibits the antidiuretic effect of vasopressin (AVP) in the conscious sheep. Pflugers Arch. 402, 360–363 (1984). https://doi.org/10.1007/BF00583936
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DOI: https://doi.org/10.1007/BF00583936